头颈癌患者肌肉健康与生活质量之间的关联：一项系统综述

文献信息

中文摘要

背景： 头颈癌（HNC）患者因代谢紊乱、营养摄入减少和治疗相关毒性而面临肌肉健康受损的风险。由于肌肉健康支持身体能力和独立性，其下降可能影响生活质量（QoL）。本系统综述考察了HNC患者肌肉健康与QoL之间的关联。
方法： 纳入标准为涉及HNC患者、使用经过验证的肌肉健康和QoL测量工具并考察其关联的研究。使用预后研究质量（QUIPS）工具评估偏倚风险。
结果： 共纳入13项研究。较差的肌肉健康与较低的总体QoL、较差的身体和角色功能、更严重的疲劳、吞咽困难、张口受限、社交进食问题以及唾液毒性相关。方法学局限性和异质性使荟萃分析无法进行。
结论： 较差的肌肉健康与HNC患者更差的QoL相关，尽管该证据不能确立因果关系。需要使用标准化测量工具的前瞻性研究。
试验注册： PROSPERO注册号：CRD42025105208。

英文摘要

BACKGROUND: Patients with head and neck cancer (HNC) are at risk of impaired muscle health due to metabolic disturbances, reduced nutritional intake, and treatment-related toxicities. Because muscle health supports physical capacity and independence, its decline may affect quality of life (QoL). This systematic review examined the association between muscle health and QoL in patients with HNC.
METHODS: Studies were included if they involved patients with HNC, used validated muscle health and QoL measures, and examined their association. Risk of bias was assessed using the Quality In Prognosis Studies (QUIPS) tool.
RESULTS: Thirteen studies were included. Poorer muscle health was associated with lower global QoL, poorer physical and role functioning, greater fatigue, swallowing difficulties, restricted mouth opening, social eating problems, and salivary toxicities. Methodological limitations and heterogeneity precluded meta-analysis.
CONCLUSIONS: Poorer muscle health was associated with worse QoL in patients with HNC, although this evidence does not establish causality. Prospective studies using standardized measures are needed.
TRIAL REGISTRATION: PROSPERO Number: CRD42025105208.