Article record

RUSH2A研究中静态视野计-OCT地形叠加分析的发现

Static Perimetry-OCT Topographical Overlay Findings in the RUSH2A Study.

临床研究耳科IF 3.3Q2

文献信息

PMID	42986169
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Audra K Miller 查看其他 22 位作者 Jacque L Duncan；Maureen G Maguire；Wendi Liang；Shobana Aravind；Isabelle Audo；Allison Ayala；Paul S Bernstein；David G Birch；Joseph Carroll；Janet K Cheetham；Todd A Durham；Abigail T Fahim；Sina Farsiu；Hiroshi Ishikawa；Mitra Adeli；Andrew Toland；Christine Kay；Lee S McDaniel；Michel Michaelides；Ajoy Vincent；Christina Y Weng；Mark E Pennesi
作者单位	Casey Eye Institute - Oregon Health & Science University, Portland, OR, USA. 查看其他 14 条单位信息 University of California, San Francisco, San Francisco, CA, USA.；Jaeb Center for Health Research, Tampa, FL, USA.；Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.；Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Centre de Référence Maladies Rares REFERET and INSERM-DGOS CIC1423, Paris, France.；Moran Eye Center, Salt Lake City, UT, USA.；Retina Foundation of the Southwest, Dallas, TX, USA.；Medical College of Wisconsin, Milwaukee, WI, USA.；Foundation Fighting Blindness, Columbia, MD, USA.；University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA.；Departments of Biomedical Engineering and Ophthalmology, Duke University, Durham, NC, USA.；Vitreo Retinal Associates, Gainesville, FL, USA.；Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.；Departments of Ophthalmology and Vision Sciences, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.；Baylor College of Medicine, Houston, TX, USA.
期刊	Translational vision science & technology
SCI 分区	Q2
IF	3.3
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

目的： 光学相干断层扫描（OCT）上的椭圆体带（EZ）缺失与静态视野计（SP）敏感度下降相关。我们在USH2A相关视网膜色素变性（RP）中探索一种地形叠加分析，以开发结构和功能变化的新型终点指标。
方法： 受试者（N = 105）接受SP检查（基线3次；此后每年1次，持续4年）和每年OCT检查。对B扫描进行分割以勾画EZ轮廓。叠加分析使用视野建模与分析（VFMA）软件，将视野山（HOV）叠加到en face红外（IR）眼底图像上，并附上从OCT容积扫描分割得到的EZ轮廓。将EZ边界及跨越EZ边界的三条条带射线投射到HOV上。测量HOV体积、HOV斜率、平均敏感度（MS）和峰值敏感度。使用混合效应模型估计变化率。
结果： 4年内，EZ内所有指标均显著下降，但斜率和峰值敏感度除外。所有条带的MS均下降，外侧条带的进展大于内侧条带。内侧条带的体积和斜率下降大于外侧条带。
结论： SP-OCT叠加分析显示EZ边缘外侧的敏感度丧失更快。EZ外侧最宽的条带进展最大，提示EZ边缘远端发生更快速的视力丧失。斜率在最宽的内侧条带内进展最明显，这可能意味着斜率变化是EZ缺失的前兆。
转化意义： 本研究利用成像和功能叠加技术，探索表征USH2A相关RP疾病进展的新型终点指标和概念。

英文摘要

PURPOSE: Ellipsoid zone (EZ) loss on optical coherence tomography (OCT) correlates with diminished sensitivity on static perimetry (SP). We explore a topographical overlay analysis in USH2A-related retinitis pigmentosa (RP) to develop novel endpoints of structural and functional change.
METHODS: Subjects (N = 105) had SP (3× baseline; once annually for 4 years) and annual OCT. B-scans were segmented to outline the EZ. Overlays used visual field modeling and analysis (VFMA) software to superimpose the hill of vision (HOV) onto the en face infrared (IR) fundus image with EZ contours segmented from OCT volume scans. EZ border and three ribbons straddling the EZ border were ray cast onto the HOV. The HOV volume, HOV slope, mean sensitivity (MS), and peak sensitivity were measured. Mixed effect models were used to estimate change rates.
RESULTS: Significant decrease over 4 years was found in all measures within the EZ, except slope and peak sensitivity. MS decreased for all ribbons, with outer ribbons showing greater progression than inner ribbons. Inner ribbons had larger decreases in volume and slope than outer ribbons.
CONCLUSIONS: SP-OCT overlay analysis showed faster loss of sensitivity outside the EZ margin. The widest ribbon outside the EZ showed greatest progression, suggesting more rapid vision loss occurring distal to the EZ margin. Slope progressed most within the widest inner ribbon, which could mean that slope change is a precursor to EZ loss.
TRANSLATIONAL RELEVANCE: This research explores novel endpoints and concepts to characterize the disease progression in USH2A-related RP using imaging and functional overlay techniques.