伴鼻息肉的慢性鼻窦炎中骨膜蛋白上调与内型及取样部位相关：一项系统综述

文献信息

中文摘要

引言： 现有文献缺乏针对支持鼻息肉（NP）中骨膜蛋白上调的研究、按内型或解剖部位进行的综合。
目的： 将不同CRSwNP内型来源的NP样本之间、NP与正常对照之间、CRSwNP患者内NP与非息肉性黏膜样本（MS）之间、以及CRSwNP患者MS与对照之间骨膜蛋白水平的差异作为主要结局。
数据综合： 嗜酸性NP（eNP）样本的骨膜蛋白水平显著高于非eNP，而非eNP样本与对照相当。CRSwNP患者NP与MS的比较显示前者骨膜蛋白mRNA和蛋白水平显著更高，而CRSwNP患者的MS与对照及CRSsNP相当。mRNA与蛋白骨膜蛋白测定之间验证了强相关性。
结论： 骨膜蛋白与嗜酸性CRSwNP高度相关，并在成熟eNP中显著上调，而非在非息肉性黏膜中。

英文摘要

INTRODUCTION: The present literature lacks an endotype- or anatomical site-targeted synthesis of the studies advocating for periostin upregulation in nasal polyps (NPs).
OBJECTIVES: Differences in periostin levels between NP samples from different CRSwNP endotypes, NP and normal controls, NP and nonpolypoidal mucosal samples (MSs) within chronic rhinosinusitis with nasal polyposis (CRSwNP) patients, and MS from CRSwNP patients and controls were considered as primary outcomes.
DATA SYNTHESIS: Eosinophilic NP (eNP) samples exhibited significantly higher periostin levels than non-eNP, while non-eNP samples were found to be comparable to controls. Comparisons between NP and MS of patients with CRSwNP attributed significantly higher periostin mRNA and protein levels in the former, while the MS of patients with CRSwNP were comparable to controls and CRSsNP. A strong correlation between mRNA and protein periostin measurements was verified.
CONCLUSION: Periostin is highly associated with eosinophilic CRSwNP and significantly upregulated in mature eNP rather than nonpolypoidal mucosa.