阻塞性睡眠呼吸暂停患者夜间缺氧负荷与主观记忆功能之间的关联
Association between nocturnal hypoxic burden and subjective memory functioning in patients with obstructive sleep apnea.
文献信息
| PMID | 42983126 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Osman Saraydar |
| 作者单位 | Department of Neurology, Faculty of Medicine, Muğla Sıtkı Koçman University, Kötekli, 48000, Muğla, Turkey. osman.saraydar.90@gmail.com. |
| 期刊 | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology |
| SCI 分区 | Q3 |
| IF | 2.7 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 阻塞性睡眠呼吸暂停（OSA）患者常报告主观记忆抱怨，但其与呼吸暂停低通气指数（AHI）的关系仍不明确。在本研究中，我们探讨了OSA患者夜间氧饱和度下降时间（T90）与主观记忆功能之间的关联。
方法： 这项前瞻性横断面研究纳入102例确诊OSA的患者。参与者被分为去饱和组（T90 ≥ 20%）和非去饱和组（T90 < 20%）。主观记忆功能采用记忆功能问卷（MFQ）评估。根据基于T90的分组和AHI定义的OSA严重程度检查MFQ总分和各分量表得分，并对多次MFQ比较应用Holm校正。在调整相关潜在混杂因素后，采用多变量线性回归分析检查连续T90与MFQ总分之间的关联。
结果： 去饱和组显示较低的MFQ总分以及部分MFQ分量表得分较低；然而，在对多次比较进行Holm校正后，这些组间差异无统计学意义。MFQ得分在AHI定义的OSA严重程度组之间无显著差异。在多变量分析中，T90与MFQ总分无独立关联，而较高的教育水平与较高的MFQ总分相关。
结论： 夜间氧饱和度下降较严重的患者表现出主观记忆功能较差的模式；然而，在对多次比较进行校正后，这些差异无统计学意义。这些发现提示，OSA中夜间低氧血症与主观记忆抱怨之间的关系可能是多因素的，并应在相关人口学和临床因素的背景下加以解释。
英文摘要
PURPOSE: Subjective memory complaints are frequently reported by patients with obstructive sleep apnea (OSA), yet their relationship with apnea-hypopnea index (AHI) remains unclear. In this study, we investigated the association between nocturnal oxygen desaturation time (T90) and subjective memory functioning in patients with OSA.
METHODS: This prospective cross-sectional study included 102 patients diagnosed with OSA. Participants were classified into desaturated (T90 ≥ 20%) and non-desaturated (T90 < 20%) groups. Subjective memory functioning was assessed using the Memory Functioning Questionnaire (MFQ). MFQ total and subscale scores were examined according to T90-based groups and AHI-defined OSA severity, with Holm correction applied for multiple MFQ comparisons. Multivariable linear regression analysis was performed to examine the association between continuous T90 and MFQ total score after adjustment for relevant potential confounders.
RESULTS: The desaturated group showed lower MFQ total scores and lower scores in selected MFQ subscales; however, these between-group differences were not statistically significant after Holm correction for multiple comparisons. MFQ scores did not differ significantly across AHI-defined OSA severity groups. In multivariable analysis, T90 was not independently associated with MFQ total score, whereas higher education level was associated with higher MFQ total scores.
CONCLUSION: Patients with greater nocturnal oxygen desaturation showed a pattern of poorer subjective memory functioning; however, these differences were not statistically significant after correction for multiple comparisons. These findings suggest that the relationship between nocturnal hypoxemia and subjective memory complaints in OSA is likely multifactorial and should be interpreted in the context of relevant demographic and clinical factors.