Article record

梅尼埃病脑MRI中的白质病变；MRI上还有更多发现？

White matter lesions in brain MRI in Meniere's disease; More findings on MRI?

临床研究耳科IF 1.7Q2

文献信息

PMID	42976488
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Alia Saberi 查看其他 7 位作者 Mehrgan Khanhakimi；Negar Hosseinpoor；Sima Fallah Arzpeyma；Mohammad Ebrahim Ghaffari；Seyed Hassan Mostafavi；Pejman Kiani；Shadman Nemati
作者单位	Neurosciences Research Center, Trauma Institute, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. 查看其他 6 条单位信息 Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.；Department of Radiology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.；Department of Biostatistics and Epidemiology, Faculty of Health, Qom University of Medical Sciences, Qom, Iran.；Iran University of Medical Sciences, Tehran, Iran.；Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.；Department of Otolaryngology and Head and Neck Surgery, Otolaryngology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: nemati@gums.ac.ir.
期刊	Auris, nasus, larynx
SCI 分区	Q2
IF	1.7
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

目的：
近年来，有人提出血管危险因素在梅尼埃病（MD）发生中的作用。对MD病例进行脑MRI以排除CPA和迷路肿瘤性病变。在本研究中，我们调查了MD患者和对照组脑MRI中血管危险因素和白质病变（WMLs）的频率。
方法：
在一项病例对照研究中，纳入30例确诊的单侧MD病例和30名作为对照组的个体（年龄18-65岁；均无偏头痛）。通过问卷收集其人口学和临床信息，并对两组进行脑MRI检查和判读。WMLs的范围采用Fazekas标准评估。
结果：
患者组和对照组在平均年龄、性别（分别为p = 0.08和p = 0.3）以及任何血管危险因素方面均无显著差异。60%的MD患者和23.33%的对照组个体在MRI上有WMLs（p = 0.004）。事实上，MD与MRI上WMLs增加近5倍相关。两组在脑室周围白质（PVWM）病变方面的差异更为显著（P = 0.032），相比之下深部白质（DWM）病变为（P = 0.052）。
结论：
尽管本研究中血管危险因素与MD之间无关联，但MD患者脑MRI中WMLs的患病率高出近5倍，尤其是PVWM型病变。看来除了检测肿瘤性病变和结构异常外，MRI在MD受试者中还有更多发现。

英文摘要

OBJECTIVE(S): Recently, the role of vascular risk factors in developing Meniere's disease (MD) has been proposed. Brain MRI has been obtained from MD cases to rule out tumor lesions in CPA and Labyrinth. In this study, we investigated the frequency of vascular risk factors and white matter lesions (WMLs) in brain MRIs of MD patients and the control group.
METHODS: In a case-control study, 30 definite unilateral MD cases and 30 individuals as the control group (aged 18-65; none had migraine) were enrolled. Their demographic and clinical information was collected through questionnaires, and brain MRI was performed and interpreted in both groups. The extent of WMLs was assessed using the Fazekas criteria.
RESULTS: The patient and control groups showed no significant differences in terms of mean age, sex (p = 0.08 and p = 0.3, respectively), and any vascular risk factors. 60% of MD patients and 23.33% of individuals in the control group had WMLs on MRI (p = 0.004). Indeed, MD was associated with a nearly 5-fold increase in WMLs in MRI. The difference between the two groups in periventricular white matter (PVWM) lesions was more significant (P = 0.032), compared with deep white matter (DWM) lesions (P = 0.052).
CONCLUSION: Despite no association between vascular risk factors and MD in this study, WMLs were nearly 5-fold more prevalent in the brain MRI of MD patients, particularly PVWM-type lesions. It seems that aside from detecting tumoral lesions and structural abnormalities, MRI has more findings in MD subjects.