Article record

基于歌唱的干预对帕金森病运动和非运动症状的系统综述

Singing-based interventions for motor and non-motor symptoms in Parkinson's disease: a systematic review.

综述 Meta咽喉科IF 5.3Q1

文献信息

PMID	42975677
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	A Trinchillo 查看其他 6 位作者 J Suh；E Marcuzzo；C Vitale；S Li Ttle；Francesca Morgante；L Ricciardi
作者单位	Department of Medical, Motor and Wellbeing Sciences, "Parthenope" University of Naples, Naples, Italy. assuntatrinchillo94@gmail.com. 查看其他 7 条单位信息 ICS Maugeri Hermitage, Naples, Italy. assuntatrinchillo94@gmail.com.；Department of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA.；Neurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.；Department of Medical, Motor and Wellbeing Sciences, "Parthenope" University of Naples, Naples, Italy.；ICS Maugeri Hermitage, Naples, Italy.；Neuromodulation and Motor Control Section, Department of Psychology and Neuroscience, School of Health and Medical Sciences, University of London, City St George's, London, UK.；Neuromodulation and Motor Control Section, Department of Psychology and Neuroscience, School of Health and Medical Sciences, University of London, City St George's, London, UK. lricciar@sgul.ac.uk.
期刊	Journal of neurology
SCI 分区	Q1
IF	5.3
研究类型	综述 Meta · 临床
所属专科	咽喉科

中文摘要

背景： 帕金森病（PD）以致残性运动和非运动症状为特征。尽管药物和康复干预可改善许多运动和非运动症状，但包括言语、吞咽、步态和平衡在内的领域仍常存在持续损害，尤其是随着疾病进展。因此，过去几年中，诸如基于歌唱的干预等替代康复方法已被用于针对言语障碍、吞咽困难、呼吸功能障碍和情绪等症状。
目的： 我们旨在综述歌唱干预对PD患者运动和非运动症状疗效的证据。
方法： 对PubMed和Google Scholar进行了全面文献检索，纳入截至2025年12月发表的干预性研究。结果被归纳为五个症状领域：运动功能、嗓音质量、呼吸、吞咽和生活质量。
结果： 共纳入26项研究，涉及1057例PD患者。基于歌唱的干预与运动症状、步态、姿势、嗓音质量、呼吸控制和最长发声时间的改善相关。若干研究还报告了心理幸福感、社会联结感和生活质量的增强，以及压力、焦虑和抑郁症状的减轻。关于吞咽结局的证据有限且不一致。研究设计、干预方案和结局指标存在相当大的异质性，妨碍了荟萃分析。
结论： 歌唱是PD康复的一种有前景的辅助疗法，尤其是在对药物治疗反应较差的领域。需要进一步的高质量研究以建立标准化方案并评估长期获益。

英文摘要

BACKGROUND: Parkinson's disease (PD) is characterized by disabling motor and non-motor symptoms. Although pharmacological and rehabilitation interventions improve many motor and non-motor symptoms, persistent impairments commonly remain in domains, including speech, swallowing, gait, and balance, particularly as the disease progresses. For this reason, over the past few years, alternative rehabilitative approaches, such as singing-based interventions, have been used with the aim of addressing symptoms, such as speech impairment, swallowing difficulties, respiratory dysfunction, and mood.
OBJECTIVE: We aim to review the evidences on the efficacy of singing interventions on motor and non-motor symptoms in patients with PD.
METHODS: A comprehensive literature search of PubMed and Google Scholar was conducted for interventional studies published until December 2025. Results were summarized into five symptom domains: motor function, voice quality, breathing, swallowing, and quality of life.
RESULTS: Twenty-six studies involving 1057 patients with PD were included. Singing-based interventions were associated with improvements in motor symptoms, gait, posture, voice quality, respiratory control, and maximum phonation time. Several studies also reported enhanced psychological well-being, social connectedness, and quality of life, with reductions in stress, anxiety, and depressive symptoms. Evidence regarding swallowing outcomes was limited and inconsistent. Considerable heterogeneity in study design, intervention protocols, and outcome measures precluded meta-analysis.
CONCLUSION: Singing is a promising adjunct therapy for PD rehabilitation, particularly in domains less responsive to pharmacological treatment. Further high-quality research is needed to establish standardized protocols and assess long-term benefits.