Article record

围绝经期女性真菌球性鼻窦炎的代谢危险因素

Metabolic risk factors for fungal ball sinusitis in perimenopausal women.

临床研究鼻科IF 3.7Q2

文献信息

PMID	42973685
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Shi-Yun Wang 查看其他 7 位作者 Wei Xu；Yue-Xi Liu；Liang Jiang；Yong Xu；Fang-Yuan Teng；Xiao-Yan Hu；Hong-Xia Li
作者单位	Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. 查看其他 4 条单位信息 Metabolic Vascular Diseases Key Laboratory of Sichuan Province, and Metabolic Vascular Diseases Key Laboratory of Sichuan-Chongqing Cooperation, Luzhou, Sichuan, China.；Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.；Department of Pathogen Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, China.；Public Center of Experimental Technology of Pathogen Biology Technology Platform, Southwest Medical University, Luzhou, Sichuan, China.
期刊	Frontiers in allergy
SCI 分区	Q2
IF	3.7
研究类型	临床研究 · 临床
所属专科	鼻科

中文摘要

目的： 真菌球性鼻窦炎（FBS）的发病率不断上升，且常见于围绝经期女性。本研究旨在探讨该特定人群中TyG-BMI、HDL-C与FBS之间的关系。
研究设计： 本单中心回顾性研究纳入2015年至2025年的FBS患者。选取45-60岁的围绝经期女性作为研究对象，并选择慢性非真菌性鼻窦炎（CNFS）患者作为对照组。比较生化指标，并按TyG-BMI四分位数对参与者进行分层。采用Logistic回归识别独立危险因素，并应用ROC曲线评估预测效能。
结果： FBS病例呈上升趋势。患者以中老年个体为主，女性患者比例显著高于男性（63.96% vs. 36.04%），女性发病高峰年龄集中在45至60岁之间。组间比较显示，FBS组的HDL-C水平显著低于CNFS组，TyG和TyG-BMI值显著高于CNFS组。随着TyG-BMI四分位数的升高，HDL-C水平逐渐下降，同时FBS患病率呈显著上升趋势（P < 0.05）。Logistic回归分析证实，HDL-C和TyG-BMI四分位数是围绝经期女性FBS的独立影响因素（分别为P = 0.008，OR = 0.482，95%CI：0.282-0.823；P = 0.04，OR = 1.192，95%CI：1.008-1.409）。ROC分析显示，TyG-BMI与HDL-C联合模型对FBS的预测价值有限。
结论： FBS的发病率逐年上升，尤其是在围绝经期女性中。HDL-C降低和TyG-BMI升高是围绝经期女性FBS的独立代谢危险因素。针对性的代谢监测和早期干预可能与较低的FBS风险相关。

英文摘要

OBJECTIVES: Rising incidence of fungal ball sinusitis (FBS) is frequently observed in perimenopausal women. This study aimed to explore the relationships between TyG-BMI, HDL-C and FBS in this specific population.
STUDY DESIGN: This single-center retrospective study enrolled FBS patients from 2015 to 2025. Perimenopausal women aged 45-60 years were selected as the study subjects, and patients with chronic non-fungal sinusitis (CNFS) were selected as the control group. Biochemical indicators were compared, and participants were stratified by TyG-BMI quartiles. Logistic regression was used to identify independent risk factors, and ROC curves were applied to assess predictive efficiency.
RESULTS: The cases of FBS showed an increasing trend. The patients were predominantly middle-aged and elderly individuals, and the proportion of female patients was significantly higher than that of males (63.96% vs. 36.04%), with the peak age of female morbidity concentrated between 45 and 60 years. Intergroup comparison demonstrated that the FBS group had significantly lower HDL-C levels and significantly higher TyG and TyG-BMI values than the CNFS group. With the elevation of TyG-BMI quartiles, the HDL-C level decreased progressively, accompanied by a significantly rising trend in the prevalence of FBS (P < 0.05). Logistic regression analysis confirmed that HDL-C and quartile of TyG-BMI were independent influence factors for FBS in perimenopausal women (P = 0.008, OR = 0.482,95%CI:0.282-0.823; P = 0.04, OR = 1.192, 95%CI:1.008-1.409; respectively). ROC analysis revealed that the combined model of TyG-BMI and HDL-C exhibited limited predictive value for FBS.
CONCLUSION: The incidence of FBS has been increasing annually, especially in perimenopausal women. Decreased HDL-C and elevated TyG-BMI are independent metabolic risk factors for FBS in perimenopausal women. Targeted metabolic monitoring and early intervention may be associated with lower FBS risk.