麻疹住院儿童住院时间相关因素及临床特征
Factors Associated with Length of Hospital Stay and Clinical Characteristics of Children Hospitalized with Measles.
文献信息
| PMID | 42973422 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Leyla Beşel |
| 作者单位 | Department of Pediatric Infectious Diseases, İstanbul Bağcılar Training and Research Hospital, İstanbul, Türkiye. |
| 期刊 | Turkish archives of pediatrics |
| SCI 分区 | Q2 |
| IF | 2 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 评估麻疹住院儿童的临床特征、并发症及与住院时间相关的因素。
材料与方法： 这项回顾性观察研究纳入2023年1月至12月在土耳其伊斯坦布尔一家三级医疗中心住院的0-18岁麻疹患儿。分析人口学、临床、实验室及住院数据。
结果： 共纳入61例麻疹住院儿童；32例（52.5%）年龄小于5岁，29例（47.5%）年龄大于5岁。59%为土耳其公民，41%为外国国籍，57.4%为男性。总体而言，77%未接种疫苗。所有患者均有发热和皮疹。肺炎是最常见的并发症（68.9%），其次为肝炎（11.5%）、龈口炎（11.5%）、眼部并发症（9.8%）和耳炎（4.9%）。所有肝炎病例均发生于5岁以上儿童。3例患者（5.2%）需要儿科重症监护。在单变量线性回归分析中，肺炎/支气管肺炎、C反应蛋白（CRP）和白细胞计数与住院时间延长显著相关。在主要多变量线性回归模型中，仅CRP仍与住院时间延长独立相关（B = 0.017，95% CI = 0.0002-0.0333；P = .047）。未发生麻疹相关死亡。
结论： 麻疹仍是一个主要公共卫生问题，尤其是在未接种疫苗的儿童中。炎症标志物与住院时间延长相关，提示全身性炎症可能促成长时间住院治疗。需要更大规模的多中心研究来证实这些发现。
英文摘要
OBJECTIVE: To evaluate the clinical characteristics, complications, and factors associated with the length of hospital stay in children hospitalized with measles.
MATERIALS AND METHODS: This retrospective, observational study included children aged 0-18 years hospitalized with measles between January and December 2023 at a tertiary care center in Istanbul, Türkiye. Demographic, clinical, laboratory, and hospitalization data were analyzed.
RESULTS: Sixty-one hospitalized children with measles were included; 32 (52.5%) were younger than 5 years and 29 (47.5%) were older than 5 years. Fifty-nine percent were Turkish citizens, 41% were foreign nationals, and 57.4% were male. Overall, 77% were unvaccinated. Fever and rash were present in all patients. Pneumonia was the most common complication (68.9%), followed by hepatitis (11.5%), gingivostomatitis (11.5%), ocular complications (9.8%), and otitis (4.9%). All hepatitis cases occurred in children older than 5 years. Three patients (5.2%) required pediatric intensive care. In univariable linear regression analyses, pneumonia/bronchopneumonia, C-reactive protein (CRP), and white blood cell count were significantly associated with longer hospital stay. In the primary multivariable linear regression model, only CRP remained independently associated with prolonged hospitalization (B = 0.017, 95% CI = 0.0002-0.0333; P = .047). No measles-related deaths occurred.
CONCLUSION: Measles remains a major public health problem, particularly among unvaccinated children. Inflammatory markers were associated with prolonged hospitalization, suggesting that systemic inflammation may contribute to longer inpatient care. Larger multicenter studies are needed to confirm these findings.