使用双光纤光学相干断层扫描系统进行实时耳蜗内距离传感与导航。
Real-Time Intracochlear Distance Sensing and Navigation Using a Dual Fiber Optical Coherence Tomography System.
文献信息
| PMID | 42970739 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Pawina Jiramongkolchai |
| 作者单位 | Department of Otolaryngology - Head and Neck Surgery, Washington University in St. Louis, St. Louis, MO. |
| 期刊 | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology |
| SCI 分区 | Q2 |
| IF | 1.9 |
| 研究类型 | 基础研究 · 基础／转化 |
| 所属专科 | 耳科 |
中文摘要
假设： 基于双光纤的光学相干断层扫描（OCT）系统可用于人耳蜗的实时耳蜗内导航和距离计算。
背景： OCT是一种无需对比剂和辐射的成像方式，可实时提供组织微解剖结构的二维和三维成像，其分辨率高于传统MRI或CT。由于OCT的基本工作原理是利用低相干干涉测量法测量背向散射近红外光的时间延迟，因此OCT可作为固有的基于光的距离传感器。
方法： 将单光纤和双光纤连接至定制构建的1310 nm扫频源（SS）OCT系统，并在耳蜗体模中验证，随后在人尸体耳蜗中测试，以计算光纤距外侧壁和内侧壁的距离。在经圆窗入路插入和回撤光纤过程中，获取光纤的曲率及其距鼓阶外侧壁和内侧壁的距离。
结果： 我们的基于光纤的SS-OCT系统可在8 µs采集速度下检测最大距离7.10 mm，轴向分辨率为10 µm。通过对双光纤使用空分复用（SDM），我们能够在无需机械旋转的情况下同时从两个空间分离位置获得距离测量。此外，我们的定制用户界面提供了即时三色编码警告系统，有助于实时微调光纤轨迹以避免耳蜗内损伤。
结论： 基于双光纤的SDM-OCT系统可用于提供实时空间导航和至耳蜗壁的距离计算。
英文摘要
HYPOTHESIS: A dual fiber-based optical coherence tomography (OCT) system can be used for real-time intracochlear navigation and distance computation in the human cochlea.
BACKGROUND: OCT is a contrast- and radiation-free modality that provides real-time 2- and 3-dimensional imaging of tissue microanatomy at higher resolutions than those of conventional MRI or CT. Because the fundamental working principle of OCT is to measure the time delay of backscattered near-infrared light using low-coherence interferometry, OCT functions as an intrinsic light-based distance sensor.
METHODS: A single- and dual-fiber attached to a custom-built 1310 nm swept-source (SS) OCT system was validated in cochlear phantoms and tested in a human cadaveric cochlea to compute the distance of the fibers from the lateral and medial walls. Curvature and distance of the fibers to the lateral and medial walls of the scala tympani were obtained during insertion and pull-back of the fibers as accessed through a round window approach.
RESULTS: Our fiber-based SS-OCT system can detect a maximum distance of 7.10 mm with an axial resolution of 10 µm at an acquisition speed of 8 µs. Using space-division multiplexing (SDM) for our dual fiber, we were able to simultaneously obtain distance measurements from 2 spatially separated locations without the need for mechanical rotation. Furthermore, our custom user interface provided an immediate 3-color-coded warning system, which facilitated real-time microadjustments of fiber trajectory to avoid intracochlear trauma.
CONCLUSION: A dual fiber-based SDM-OCT system can be used to provide real-time spatial navigation and distance calculation to the cochlear walls.