突发性聋患者接受鼓室内皮质类固醇注射的患者报告体验：一项单中心前瞻性研究

文献信息

中文摘要

背景： 鼓室内皮质类固醇（ITC）注射被推荐作为突发性感音神经性聋（SSHL）发病后2-6周恢复不完全患者的挽救治疗。
目的： 评估患者对ITC治疗的体验并评价治疗副作用。
材料与方法： 前瞻性纳入15例符合ITC治疗条件的SSHL患者，共接受43次ITC注射。患者在每次注射前后以及2周和3个月随访时完成关于治疗相关和疾病相关症状及副作用的问卷，采用视觉模拟量表（VAS）评分。评估听力学结局。
结果： 治疗相关不适较轻，麻醉应用时疼痛的平均VAS评分<2，注射时疼痛的平均VAS评分<3。12例患者认为该治疗值得付出，无人后悔参与研究。末次注射后2周，无患者报告残留副作用；然而，许多患者在3个月随访时仍报告残留听力损失、声音敏感、耳鸣和头晕。
结论与意义： 患者对ITC治疗耐受良好。SSHL发病后3个月报告的症状凸显未来SSHL研究除听力恢复外还需关注耳鸣、声音敏感和头晕。

英文摘要

BACKGROUND: Intratympanic corticosteroid (ITC) injections are recommended as salvage therapy for patients with incomplete recovery 2-6 weeks after the onset of sudden sensorineural hearing loss (SSHL).
AIMS/OBJECTIVES: To evaluate patient experiences with ITC therapy and assess treatment side effects.
MATERIAL AND METHODS: Fifteen patients with SSHL eligible for ITC therapy were prospectively enrolled and received a total of 43 ITC injections. They completed questionnaires on treatment- and disease-related symptoms and side effects, rated using a visual analogue scale (VAS), before and after each injection and at 2-week and 3-month follow-up. Audiometric outcomes were assessed.
RESULTS: Treatment-related discomfort was low, with mean VAS scores <2 for pain at anaesthesia application and <3 for pain at injection. Twelve patients found the treatment worth the effort, and none regretted participating in the study. Two weeks after the last injection, none of the patients reported residual side effects; however, many patients reported residual hearing loss, sensitivity to sound, tinnitus, and dizziness also at the 3-month follow-up.
CONCLUSIONS AND SIGNIFICANCE: ITC treatment was well-tolerated by patients. The symptoms reported at 3 months after SSHL onset highlights the need for future SSHL studies to address tinnitus, sound sensitivity, and dizziness in addition to hearing recovery.