HPV状态与T1-T2口咽癌经口机器人手术后生活质量的相关性
Association of HPV Status With Quality of Life After Transoral Robotic Surgery for T1-T2 Oropharyngeal Carcinoma.
文献信息
| PMID | 42968417 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Paolo Tesauro |
| 作者单位 | Service of Head and Neck Oncology, DACI Department, Gustave Roussy, University Paris-Saclay, Villejuif, France. |
| 期刊 | Head & neck |
| SCI 分区 | Q1 |
| IF | 2.5 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
背景： 在T1-T2口咽鳞状细胞癌（OPSCC）中，经口机器人手术（TORS）后与患者报告生活质量相关的因素尚不明确。
方法： 回顾性队列研究纳入59例接受TORS治疗的T1-T2 OPSCC患者。采用混合效应模型分析吞咽相关生活质量（MD安德森吞咽困难量表，MDADI）及EORTC QLQ-C30/QLQ-H&N35评分，模型校正HPV状态、亚部位、辅助治疗，并在敏感性分析中校正生活方式因素、年龄、肿瘤分期及术前评分。
结果： HPV阳性状态与较高的MDADI评分独立相关（β=12.39，p=0.001），在校正术前评分后仍相关（β=16.0，p=0.004），并与较低的QLQ-H&N35症状负担相关（β=-9.5，p=0.012）。辅助放疗与较低的MDADI评分相关（β=-7.92，p=0.021），校正肿瘤分期后该关联减弱。肿瘤亚部位与结局无关。
结论： HPV阳性患者在TORS后报告更好的吞咽相关生活质量，且独立于术前评分。
英文摘要
BACKGROUND: In T1-T2 oropharyngeal squamous cell carcinoma (OPSCC), factors associated with patient-reported quality of life after transoral robotic surgery (TORS) are poorly defined.
METHODS: Retrospective cohort of 59 patients with T1-T2 OPSCC treated with TORS. Swallowing-related quality of life (MD Anderson Dysphagia Inventory, MDADI) and EORTC QLQ-C30/QLQ-H&N35 scores were analyzed with mixed-effects models adjusted for HPV status, subsite, adjuvant treatment and, in sensitivity analyses, lifestyle factors, age, tumor stage, and preoperative scores.
RESULTS: HPV-positive status was independently associated with higher MDADI scores (β = 12.39, p = 0.001), including after adjustment for preoperative scores (β = 16.0, p = 0.004), and with lower QLQ-H&N35 symptom burden (β = -9.5, p = 0.012). Adjuvant radiotherapy was associated with lower MDADI scores (β = -7.92, p = 0.021), attenuated after adjustment for tumor stage. Tumor subsite was not associated with outcomes.
CONCLUSIONS: HPV-positive patients report better swallowing-related quality of life after TORS, independently of preoperative scores.