载脂蛋白B/载脂蛋白A比值升高与突发性感音神经性听力损失风险增加相关。
Elevated ApoB/ApoA ratio is associated with increased risk of sudden sensorineural hearing loss.
文献信息
| PMID | 42959176 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Zhisong Yan |
| 作者单位 | Department of Otolaryngology, Tongzhou Branch of Nantong People's Hospital (Nantong Tongzhou People's Hospital), Nantong, Jiangsu, China. |
| 期刊 | Frontiers in endocrinology |
| SCI 分区 | Q1 |
| IF | 6 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 探讨中国南通地区载脂蛋白B与载脂蛋白A（ApoB/ApoA）比值与突发性感音神经性听力损失（SSNHL）风险之间的关联。
方法： 本横断面研究纳入1211名参与者（674名听力正常者，537名SSNHL患者）。比较基线人口学特征、合并症及生化指标。采用多变量logistic回归评估ApoB/ApoA比值与SSNHL风险之间的独立关联。应用逆概率处理加权（IPTW）和倾向性评分匹配（PSM）进行敏感性分析。还进行了分层分析和剂量-反应分析。
结果： 两组在年龄、性别、高血压、BMI及多种代谢标志物方面存在显著差异（均P < 0.05）。在完全校正模型中，ApoB/ApoA比值升高与SSNHL风险增加显著相关（OR = 9.34，95% CI：3.93-22.21）。该正相关在PSM后仍保持稳健（OR = 8.79，95% CI：3.26-23.66）。IPTW分析显示，高比值组（0.78-1.34）的SSNHL风险高于低比值组（0.13-0.58）（OR = 2.28，95% CI：1.79-2.90）。剂量-反应分析表明，该比值与SSNHL患病率之间存在显著的线性正相关，无论是在PSM前还是PSM后。分层分析表明，该关联在年龄、性别、高血压和糖尿病亚组中保持一致（交互作用P值均 > 0.05）。
结论： 高ApoB/ApoA比值与SSNHL风险增加存在显著的线性正相关。它可作为SSNHL风险评估的独立临床生物标志物，为代谢管理提供依据。
英文摘要
OBJECTIVE: To investigate the association between the apolipoprotein B to apolipoprotein A (ApoB/ApoA) ratio and sudden sensorineural hearing loss (SSNHL) risk in Nantong, China.
METHODS: This cross-sectional study included 1211 participants (674 with normal hearing, 537 with SSNHL). Baseline demographics, comorbidities, and biochemical indicators were compared. Multivariable logistic regression evaluated the independent association between the ApoB/ApoA ratio and SSNHL risk. Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were applied for sensitivity analysis. Stratified and dose-response analyses were also conducted.
RESULTS: The groups differed significantly in age, sex, hypertension, BMI, and various metabolic markers (all P < 0.05). In the fully adjusted model, an elevated ApoB/ApoA ratio was significantly associated with increased SSNHL risk (OR = 9.34, 95% CI: 3.93-22.21). This positive association remained robust after PSM (OR = 8.79, 95% CI: 3.26-23.66). IPTW analysis showed the high-ratio group (0.78-1.34) had a higher SSNHL risk than the low-ratio group (0.13-0.58) (OR = 2.28, 95% CI: 1.79-2.90). Dose-response analysis indicated a significant linear positive correlation between the ratio and SSNHL prevalence, both before and after PSM. Stratified analyses demonstrated this association remained consistent across age, sex, hypertension, and diabetes subgroups (all P for interaction > 0.05).
CONCLUSION: A high ApoB/ApoA ratio has a significant linear positive association with increased SSNHL risk. It serves as an independent clinical biomarker for SSNHL risk assessment, providing a basis for metabolic management.