Article record

美国40-85岁成人全身炎症指数与听力损失：1999-2020年系列横断面研究

Systemic Inflammatory Indices and Hearing Loss in U.S. Adults Aged 40-85 Years: A Serial Cross-Sectional Study 1999-2020.

临床研究耳科IF 3.2Q2

文献信息

PMID	42958623
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Yulu Zheng 查看其他 7 位作者 Zheng Guo；Lei Zhao；Xingguo Peng；Yahong Zhu；Guangle Shan；Tingting Li；Xingang Li
作者单位	Centre for Precision Health, Edith Cowan University, Joondalup, Australia. 查看其他 5 条单位信息 Department of Otorhinolaryngology, Heze Municipal Hospital, Heze, China.；Qinghai University Affiliated Hospital, Xining, China.；School of Science, Edith Cowan University, Joondalup, Australia.；Department of Bioinformatics, Thrive Bioresearch, Beijing, China.；Medical Research Center, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China.
期刊	Immunity, inflammation and disease
SCI 分区	Q2
IF	3.2
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

目的： 全身炎症指数与免疫衰老相关疾病有关，但尚未在听力损失中进行充分研究。本研究旨在确定全身炎症指数是否与中年及晚年听力损失相关。
方法： 这项系列横断面、基于社区的研究在美国1999-2020年国家健康与营养调查中开展。听力损失定义为较好耳在0.5、1、2和4 kHz的纯音平均听阈≥20分贝听力级。六项全身炎症指数包括全身炎症反应指数（SIRI）、全身免疫炎症指数（SII）、全免疫炎症值（PIV）、中性粒细胞淋巴细胞比值（NLR）、血小板淋巴细胞比值（PLR）和淋巴细胞单核细胞比值（LMR）。采用改良Poisson回归模型（校正潜在混杂因素）得出的患病率比（PR）及95%置信区间（CI）表示各全身炎症指数与听力损失之间的关联。
结果： 共纳入7920名40-85岁成人。平均（标准差）年龄为58.6（11.8）岁，4310名（54.4%）为女性，2262名（28.6%）存在听力损失。校正后，听力损失与SIRI（PR 1.14，95% CI 1.08-1.20）、SII（PR 1.07，95% CI 1.02-1.13）、PIV（PR 1.11，95% CI 1.06-1.16）、NLR（PR 1.10，95% CI 1.04-1.17）和LMR（PR 0.87，95% CI 0.81-0.94）相关。
结论： 本研究为全身炎症指数与听力损失之间的关联提供了见解，对风险分层具有潜在意义。尽管这些指数是听力损失成人慢性炎症的潜在指标，但仍需进一步的外部验证。

英文摘要

OBJECTIVE: Systemic inflammatory indices, linked to immunosenescence-related diseases, have not been thoroughly studied in hearing loss. This study aimed to determine whether systemic inflammatory indices are associated with hearing loss in midlife and later life.
METHODS: This serial cross-sectional, community-based investigation was conducted within the National Health and Nutrition Examination Survey 1999-2020 in United States. Hearing loss was defined as a pure-tone average of ≥ 20 decibel hearing level at 0.5, 1, 2, and 4 kHz in the better ear. Six systemic inflammatory indices included systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and lymphocyte monocyte ratio (LMR). Prevalence ratios (PRs) with 95% confidence intervals (CIs) derived from modified Poisson regression models (with adjustment for potential confounding factors) represented the associations between each systemic inflammatory index and hearing loss.
RESULTS: A total of 7920 adults aged 40-85 years were included. The mean (standard deviation) age was 58.6 (11.8) years, 4310 (54.4%) were women, and 2262 (28.6%) had hearing loss. After adjustment, hearing loss was associated with SIRI (PR 1.14, 95% CI, 1.08-1.20), SII (PR 1.07, 95% CI, 1.02-1.13), PIV (PR 1.11, 95% CI, 1.06-1.16), NLR (PR 1.10 95% CI, 1.04-1.17), and LMR (PR 0.87, 95% CI, 0.81-0.94).
CONCLUSION: This study provides insights into the associations between systemic inflammatory indices and hearing loss, offering potential implications for risk stratification. While these indices are potential indicators for chronic inflammation in adults with hearing loss, further external validations are needed.