Article record

美国吸入相关性呼吸衰竭的死亡率趋势：多死因分析

Mortality trends of aspiration-associated respiratory failure in the united states : a multiple cause of death analysis.

临床研究咽喉科IF 4.8Q1

文献信息

PMID	42958142
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Taha Alam 查看其他 12 位作者 Ehsanullah Alokozay；Sohaima Kamal；Fnu Areesha；Muhammad Ibrahim Rashid；Iman Osman Abufatima；Noor Un Nisa；Muhammad Junaid Azhar；Amber Alam；Ali Chand；Nafila Zeeshan；Mahwish Gulbahar；Alem Mehari
作者单位	Dow University of Health Sciences, Karachi, Pakistan. 查看其他 7 条单位信息 Faculty of Medicine, Kandahar University, District # 10, Kandahar, 3801, Afghanistan. hebibzaiehsanullah@gmail.com.；Bahria University College of Medicine, Bahria University, Islamabad, Pakistan.；University of Medical Sciences and Technology, Khartoum, Sudan.；Jinnah Sindh Medical University, Karachi, Pakistan.；Department of Medicine, Howard University Hospital, Washington, DC, USA.；Khyber Medical University, Peshawar, Khyber Pakhtunkhwa, Pakistan.；Shaheed Mohtarma Benazir Bhutto Medical College, Lyari, Karachi, Pakistan.
期刊	BMC public health
SCI 分区	Q1
IF	4.8
研究类型	临床研究 · 临床
所属专科	咽喉科

中文摘要

背景： 吸入相关性呼吸衰竭是美国成人发病和死亡的一个重要但未被充分认识的原因。尽管具有临床意义，其全国流行病学模式和人口学差异仍缺乏充分描述。
方法： 从CDC WONDER数据库提取1999-2023年美国年龄≥25岁成人中将吸入和呼吸衰竭列为根本或 contributing 死因的死亡率数据。计算年龄调整死亡率（AAMR）。采用Joinpoint回归估计年度百分比变化（APC）和年度平均百分比变化（AAPC）及其95%置信区间（CI）。
结果： 1999年至2023年间，共识别出372,764例涉及吸入相关性呼吸衰竭的美国年龄≥25岁成人死亡。年龄调整死亡率从4.27/10万上升至10.17/10万（AAPC：3.98%；p<0.001）。男性平均AAMR高于女性（8.94 vs. 4.72/10万）。年龄≥65岁成人的粗死亡率最高（27.79/10万）。非西班牙裔非裔美国人（7.10）和美国印第安人/阿拉斯加原住民人群（6.61）的平均AAMR最高，而大都市地区的AAMR略高于非大都市地区（5.99 vs. 5.40）。
结论： 1999年至2023年间，涉及吸入相关性呼吸衰竭的死亡率显著上升，并存在显著的人口学和地理差异。这些发现支持改进吞咽困难的预防、监测和有针对性的公共卫生干预。

英文摘要

BACKGROUND: Aspiration-associated respiratory failure is an important but under-recognized cause of morbidity and mortality among U.S. adults. Despite its clinical significance, national epidemiologic patterns and demographic disparities remain poorly characterized.
METHODS: Mortality data from the CDC WONDER Database (1999-2023) were extracted for adults aged ≥ 25 years in the U.S. with Aspiration and Respiratory Failure listed as underlying or contributing causes of death. Age-adjusted mortality rates (AAMRs) were calculated. Joinpoint regression was used to estimate the Annual Percent Change (APC) and Annual Average Percentage Change (AAPC) with 95% confidence intervals (CIs).
RESULTS: Between 1999 and 2023, 372,764 deaths involving aspiration-associated respiratory failure were identified among U.S. adults aged ≥ 25 years. The age-adjusted mortality rate increased from 4.27 to 10.17 per 100,000 population (AAPC: 3.98%; p < 0.001). Males had higher mean AAMRs than females (8.94 vs. 4.72 per 100,000). Adults aged ≥ 65 years had the highest crude mortality rate (27.79 per 100,000). Non-Hispanic African Americans (7.10) and American Indian/Alaska Native populations (6.61) had the highest mean AAMRs, while metropolitan areas had slightly higher AAMRs than non-metropolitan areas (5.99 vs. 5.40).
CONCLUSION: Mortality involving aspiration-associated respiratory failure increased significantly from 1999 to 2023, with substantial demographic and geographic disparities. These findings support improved dysphagia prevention, surveillance, and targeted public health interventions.