慢性咳嗽且体重指数相对较低患者中疑似阻塞性睡眠呼吸暂停的患病率
Prevalence of Suspected Obstructive Sleep Apnea Among Patients With Chronic Cough and Relatively Low BMI.
文献信息
| PMID | 42957264 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Natsuhiko Iwamoto |
| 作者单位 | Division of Respiratory Medicine, Kobe University Hospital, Kobe, Japan. |
| 期刊 | In vivo (Athens, Greece) |
| SCI 分区 | Q3 |
| IF | 1.8 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
背景/目的： 近期研究提示慢性咳嗽与阻塞性睡眠呼吸暂停（OSA）之间存在关联。本研究旨在估计日本成人慢性咳嗽患者中疑似OSA的患病率，并描述相关临床特征。
患者与方法： 2023年3月至2025年2月期间，从三家日本机构招募慢性咳嗽门诊患者。符合条件的参与者为年龄≥20岁且咳嗽持续>8周者。进行夜间家庭睡眠呼吸暂停检测以评估呼吸事件指数（REI），疑似OSA定义为REI≥5次/小时。使用视觉模拟量表（VAS）和日本版莱斯特咳嗽问卷（J-LCQ）评估咳嗽相关症状，并使用Epworth嗜睡量表（ESS）评估日间嗜睡。比较不同慢性咳嗽病因间的REI。按REI≥15次/小时对患者进行分层。评估REI与年龄、体重指数（BMI）、VAS评分和J-LCQ评分之间的相关性。
结果： 本研究纳入23例患者（中位年龄56.0岁；11例男性）。中位BMI为25.2 kg/m2。尽管中位ESS评分为7.0，仍有20例患者（87.0%）存在疑似OSA。中位REI为15.6次/小时，且无论慢性咳嗽病因为何均升高。REI≥15次/小时与年龄较大相关（p=0.04），而BMI在组间无显著差异。J-LCQ评分与REI无显著关联。
结论： 慢性咳嗽患者的REI较高，提示尽管其BMI相对较低，疑似OSA的患病率仍较高。这些发现提示存在不依赖肥胖的机制，并支持即使无日间嗜睡的患者也应进行OSA筛查。
英文摘要
BACKGROUND/AIM: Recent studies have suggested an association between chronic cough and obstructive sleep apnea (OSA). This study aimed to estimate the prevalence of suspected OSA and describe associated clinical characteristics among Japanese adults with chronic cough.
PATIENTS AND METHODS: Outpatients with chronic cough were recruited from three Japanese institutions between March 2023 and February 2025. Eligible participants were ≥20 years old with a cough lasting >8 weeks. Overnight home sleep apnea testing was performed to assess the respiratory event index (REI), and suspected OSA was defined as an REI ≥5 events/h. Cough-related symptoms were assessed using the visual analog scale (VAS) and the Japanese version of the Leicester Cough Questionnaire (J-LCQ), and daytime sleepiness was evaluated using the Epworth Sleepiness Scale (ESS). REI was compared across causes of chronic cough. Patients were stratified by REI ≥15 events/h. Correlations between the REI and age, body mass index (BMI), VAS score, and J-LCQ score were evaluated.
RESULTS: This study enrolled 23 patients (median age, 56.0 years; 11 men). The median BMI was 25.2 kg/m2. Suspected OSA was present in 20 patients (87.0%), despite a median ESS score of 7.0. The median REI was 15.6 events/h and was elevated regardless of the cause of chronic cough. REI ≥ 15 events/h was associated with older age (p=0.04), whereas BMI did not differ significantly between the groups. J-LCQ scores were not significantly associated with the REI.
CONCLUSION: REI was high in patients with chronic cough, suggesting a high prevalence of suspected OSA despite their relatively low BMI. These findings suggest obesity-independent mechanisms and support OSA screening even in patients without daytime sleepiness.