Article record

阻塞性睡眠呼吸暂停与精液质量下降及精液局部炎症相关：一项前瞻性队列研究并附非随机CPAP随访

Obstructive sleep apnoea is associated with reduced semen quality and compartmentalized seminal inflammation: A prospective cohort with non-randomized CPAP follow-up.

临床研究咽喉科IF 4.5Q1

文献信息

PMID	42956565
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Yang Ji 查看其他 19 位作者 Hongxia Wang；Minmin Lv；Aiming Tan；Fu Shi；Jiangxia Shi；Yingying Zong；Lin Jiang；Chun Ning；Qiong Zhang；Min Liu；Hui Zeng；Yanna Li；Wenliang Wang；Keke Zhang；Chi-Leung David Lam；Emmanuele A Jannini；Lei Rong；Lingwei Wang；Yong-Gang Duan
作者单位	Jinan University, Guangzhou, Guangdong Province, China; Department of Respiratory Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China. 查看其他 9 条单位信息 Department of Respiratory Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China.；Department of Research Administration, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China.；Shenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China.；The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China.；Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.；Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier, Roma, Italy.；Department of Respiratory Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China. Electronic address: ronglei@hku-szh.org.；Department of Respiratory Medicine, Shenzhen People's Hospital, Shenzhen, Guangdong Province, China. Electronic address: limey@sina.com.；Shenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China. Electronic address: duanyg@hku-szh.org.
期刊	Sleep medicine
SCI 分区	Q1
IF	4.5
研究类型	临床研究 · 临床
所属专科	咽喉科

中文摘要

背景： 阻塞性睡眠呼吸暂停（OSA）与全身性炎症及男性生殖功能障碍相关，但其与精液质量及精液局部炎症的关系仍不明确。
目的： 探讨OSA与精液参数、勃起功能及炎症谱的关联，并评估持续气道正压通气（CPAP）治疗后这些标志物的纵向变化。
方法： 本前瞻性研究纳入72例育龄期OSA男性及22例非OSA对照。多导睡眠监测仅在基线时进行。在CPAP随访期间，通过设备记录的使用小时数及残余呼吸暂停-低通气指数确定治疗有效性。评估勃起功能（IIEF-5）、精液质量及血清/精液细胞因子。
结果： 与对照相比，OSA患者的总精子活力和前向运动精子活力及精液量显著降低，同时精液IL-1β、IL-6、IL-10和IL-17A升高，而血清细胞因子或勃起功能无相应变化。在CPAP随访期间，依从性良好的患者在治疗后最早1个月即表现出前向运动精子活力的早期改善。睡眠结构破坏和精液局部炎症与精液质量下降独立相关。
结论： OSA与精液质量下降及精液局部炎症相关，而无相应的全身性或勃起功能变化。CPAP治疗伴随精子活力的纵向改善，提示对于表现为不明原因精液异常的男性，可考虑将睡眠呼吸障碍评估作为探索性检查。

英文摘要

BACKGROUND: Obstructive sleep apnoea (OSA) is associated with systemic inflammation and male reproductive dysfunction, but its relationship with semen quality and local seminal inflammation remains unclear.
OBJECTIVES: To investigate the associations of OSA with semen parameters, erectile function, and inflammatory profiles, and to assess longitudinal changes in these markers following continuous positive airway pressure (CPAP) therapy.
METHODS: This prospective study enrolled 72 reproductive-aged men with OSA and 22 non-OSA controls. Polysomnography was performed at baseline only. During CPAP follow-up, treatment efficacy was ascertained from device-recorded hours of use and residual apnoea-hypopnoea index. Erectile function (IIEF-5), semen quality, and serum/seminal cytokines were assessed.
RESULTS: Compared with controls, OSA patients showed significantly lower total and progressive sperm motility and semen volume, along with elevated seminal IL-1β, IL-6, IL-10, and IL-17A, without corresponding changes in serum cytokines or erectile function. During CPAP follow-up, adherent patients demonstrated early improvements in progressive sperm motility as early as 1 month post-treatment. Sleep architecture disruption and local seminal inflammation were independently associated with reduced semen quality.
CONCLUSION: OSA is associated with reduced semen quality and localized seminal inflammation, without corresponding systemic or erectile changes. CPAP therapy is accompanied by longitudinal improvements in sperm motility, suggesting that evaluation for sleep-disordered breathing may be considered an exploratory assessment in men presenting with unexplained semen abnormalities.