用于耳蜗内耳蜗电图应用的外周听觉系统集成计算模型

文献信息

中文摘要

耳蜗电图（ECochG）测量内耳的电反应，对于在人工耳蜗植入过程中监测耳蜗健康具有重要价值。然而，其解读并不简单，现有听觉模型缺乏生理细节且在高刺激强度下的有效性不足。我们提出了外周听觉系统联合模型（CPAS），该模型结合生物物理内毛细胞和外毛细胞模型用于ECochG仿真。与以往分别聚焦单一细胞类型并输出感受器电位的毛细胞模型不同，CPAS无需经验缩放因子即可直接计算细胞外电流。该模型将双共振非线性基底膜滤波器与电毛细胞电路耦合，并在多个刺激强度下依据动物数据进行了验证。CPAS通过聚焦高刺激强度（即临床记录耳蜗内ECochG的强度范围）的ECochG仿真进行评估。仿真的耳蜗内ECochG反应显示出预期的时间、频谱和空间特征。CPAS为ECochG建模提供了框架，其生物物理参数原则上可表征病理生理变化，为未来听力损伤研究提供了基础。

英文摘要

Electrocochleography (ECochG) measures electrical responses in the inner ear and is valuable for monitoring cochlear health during cochlear implantation. Yet, its interpretation is not straightforward, and available auditory models lack physiological detail and validity at high stimulus levels. We present the combined model of the peripheral auditory system (CPAS), which combines biophysical inner and outer hair cell models for ECochG simulation. Unlike previous hair cell models that focused on either cell type separately and output receptor potentials, CPAS directly computes extracellular currents without empirical scaling factors. The model couples a dual-resonance nonlinear basilar membrane filter with electrical hair cell circuits validated against animal data at multiple stimulus levels. CPAS is evaluated with ECochG simulations focused on high stimulus levels - the range at which intracochlear ECochG is clinically recorded. Simulated intracochlear ECochG responses demonstrate expected temporal, spectral, and spatial characteristics. CPAS provides a framework for ECochG modeling, and its biophysical parameters can in principle represent pathophysiological changes, providing a basis for future investigation of hearing impairment.