狨猴的口部运动功能网络

文献信息

中文摘要

背景： 灵长类动物的交流依赖于口面部复合体的精确协调。虽然新世界猴正日益成为发声交流研究的模型，但其口部运动控制背后的神经基础仍研究不足。方法：在此，我们使用超高场fMRI在清醒的普通狨猴（Callithrix jacchus）中绘制了在自发性可见口部运动功能（包括下颌和唇部运动、伸舌、吞咽和发声）期间参与的全脑神经网络，并将其与处理同种个体叫声的听觉加工所招募的网络区分开来。结果：所得的口部运动图谱揭示了一个广泛的控制基质，其范围超出初级感觉运动皮层，涵盖背侧前额叶（8aD、8b区）、中扣带回、后顶叶区（PF、PFG和PE）以及听觉区域。顶叶的参与提示感觉运动整合在狨猴口部运动控制中发挥作用。在皮层下，该网络涉及丘脑、基底神经节和小脑，并在延髓网状结构和导水管周围灰质（参与节律性口部运动控制的脑干区域）中有额外激活。以背侧为主的激活模式以及有限的腹侧前运动区参与定义了该网络，并为该物种发声运动控制的未来研究提供了基础框架，也为据推测言语由此进化而来的节律性口部运动基质提供了比较参考。结论：无

英文摘要

Primate communication relies on the precise coordination of the orofacial complex. While New World monkeys are growing models for vocal communication research, the neural basis underlying their oromotor control remains underexplored. Here, we used ultra-high-field fMRI in awake common marmosets (Callithrix jacchus) to map the whole-brain neural networks engaged during spontaneous visible oromotor functions-including jaw and lip movements, tongue protrusion, swallowing, and vocalization-distinct from those recruited during the auditory processing of conspecific calls. The resulting oromotor maps reveal a widespread control substrate extending beyond primary sensorimotor cortices, encompassing dorsal prefrontal (areas 8aD, 8b), mid-cingulate, posterior parietal areas (PF, PFG, and PE), and auditory regions. The parietal engagement points to a role for sensorimotor integration in marmoset oromotor control. Subcortically, this network engages the thalamus, basal ganglia, and cerebellum, with additional activation in the medullary reticular formation and periaqueductal gray, brainstem regions implicated in rhythmic oromotor control. A predominantly dorsal pattern of activation, with limited ventral premotor engagement, defines this network and provides a foundational framework for future studies of vocal-motor control in this species and a comparative reference for the rhythmic oromotor substrates from which speech is hypothesized to have evolved.