合成GM-CSF活性中心肽的抗病毒作用机制
Antiviral Action Mechanisms of a Synthetic GM-CSF Active-Center Peptide.
文献信息
| PMID | 42944044 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Aleksandr Zurochka |
| 作者单位 | Federal Budgetary Institution of Science, «Federal Scientific Research Institute of Viral Infections «Virome»», Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Ekaterinburg 620030, Russia. |
| 期刊 | Viruses |
| SCI 分区 | Q2 |
| IF | 3.8 |
| 研究类型 | 基础研究 · 基础／转化 |
| 所属专科 | 咽喉科 |
中文摘要
我们评估了一种合成GM-CSF活性中心肽对多种含RNA和DNA、包膜和非包膜病毒的抗病毒活性。我们在人喉癌HEp-2细胞连续培养中，体外和体内评价了其对副流感病毒3型（Vok株）和腺病毒3型（3/Voronezh/2174/82株）的抗病毒活性。针对人腺病毒5型、柯萨奇病毒B3、埃可病毒30型、甲型流感病毒A/Puerto Rico/8/34（H1N1）、人副流感病毒3型、单纯疱疹病毒1型、OC43冠状病毒和人巨细胞病毒，在各种允许细胞系中扩增后评估了杀病毒活性。该肽表现出比ZP2肽制剂更强的预防作用，并对包膜RNA病毒显示出优先活性。我们在体外未检测到ZP2对HEp-2细胞的细胞毒性作用。
英文摘要
We assessed the antiviral activity of a synthetic GM-CSF active-center peptide against a number of RNA- and DNA-containing viruses, both enveloped and nonenveloped. We evaluated the antiviral activity in vitro and in vivo against parainfluenza virus type 3 (strain Vok) and adenovirus serotype 3 (strain 3/Voronezh/2174/82) in a continuous culture of human laryngeal carcinoma HEp-2 cells. Virucidal activity was evaluated against human adenovirus type 5, Coxsackievirus B3, Echovirus 30 virus, influenza virus A/Puerto Rico/8/34 (H1N1), human parainfluenza virus type 3, herpes simplex virus type 1, OC43 coronavirus, and human cytomegalovirus propagated in various permissive cell lines. The peptide exhibited a stronger prophylactic effect than the ZP2 peptide preparation and showed preferential activity against enveloped RNA viruses. We detected no cytotoxic effect of ZP2 on HEp-2 cells in vitro.