持续性姿势-知觉性头晕中静息态神经振荡与功能连接的改变
Altered Resting-State Neural Oscillations and Functional Connectivity in Persistent Postural-Perceptual Dizziness.
文献信息
| PMID | 42939309 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Feng Li |
| 作者单位 | Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, No. 264 Guangzhou Road, Nanjing 210029, China. |
| 期刊 | Brain sciences |
| SCI 分区 | Q2 |
| IF | 3.6 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
背景： 持续性姿势-知觉性头晕（PPPD）是一种慢性功能性神经耳科疾病，以持续性头晕、不稳感和视觉依赖为特征。其电生理机制尚不清楚。本研究考察了PPPD患者的静息态脑电频谱功率和功能连接及其与姿势稳定性和临床症状的关联。
方法： 研究纳入40例PPPD患者和40例年龄、性别匹配的健康对照，进行闭眼静息态脑电记录。采用Pro-Kin系统测量静态姿势稳定性。计算delta、theta、alpha、beta和gamma频段的频谱功率。使用加权相位滞后指数评估功能连接。
结果： 静态姿势描记显示，与健康对照相比，PPPD患者的姿势稳定性受损。频谱功率分析显示，额区和左侧顶枕区theta频段相对功率增加。连接性分析显示，theta频段前额-颞叶连接增加、颞-枕叶连接减少；alpha频段额-顶-枕叶连接增加、顶-颞叶连接减少；gamma频段小脑与颞叶、中央区连接减少。
结论： PPPD与涉及认知-情感、视觉和感觉运动网络的静息态皮层振荡及功能连接的频率特异性改变相关。静息态脑电可能有助于刻画PPPD的网络层面异常。
英文摘要
Background: Persistent postural-perceptual dizziness (PPPD) is a chronic functional neuro-otologic disorder marked by persistent dizziness, unsteadiness, and visual dependence. Its electrophysiological mechanisms remain unclear. This study examined resting-state EEG spectral power and functional connectivity in PPPD and their associations with postural stability and clinical symptoms. Methods: Forty patients with PPPD and 40 age- and sex-matched healthy controls were studied with an eyes-closed resting-state EEG recording. Static postural stability was measured with the Pro-Kin system. Spectral power was calculated for delta, theta, alpha, beta, and gamma bands. Functional connectivity was assessed using the weighted phase lag index. Results: Static posturography showed impaired postural stability in patients with PPPD compared with healthy controls. Spectral power analysis showed increased theta-band relative power over the frontal and left parieto-occipital regions. Connectivity analysis showed increased prefrontal-temporal and decreased temporal-occipital connectivity in the theta band, increased fronto-parieto-occipital and decreased parietal-temporal connectivity in the alpha band, and decreased cerebellar and temporal, central connectivity in the gamma band. Conclusions: PPPD was associated with frequency-specific alterations in resting-state cortical oscillations and functional connectivity involving cognitive-affective, visual, and sensorimotor networks. Resting-state EEG may help characterize network-level abnormalities in PPPD.