双向孟德尔随机化分析揭示类风湿关节炎与急性鼻窦炎之间的因果关系

文献信息

中文摘要

本研究采用双向孟德尔随机化（两样本孟德尔随机化）分析，探讨类风湿关节炎（RA）与急性鼻窦炎（AS）之间的因果关系。我们使用公开的全基因组关联研究数据集，识别与RA和AS均相关的单核苷酸多态性。随后，我们应用包括逆方差加权、MR-Egger回归和加权中位数在内的统计方法，评估这两种疾病之间的因果效应。本研究通过两样本孟德尔随机化分析提供证据，提示RA可能是AS的独立危险因素。这凸显了免疫调节在The与AS之间遗传重叠中的作用，为未来免疫疾病机制研究以及潜在的临床预防和治疗策略提供了新视角。

英文摘要

This study explored the causal relationship between RA and acute sinusitis (AS) using a bidirectional Mendelian randomization (two-sample Mendelian randomization) analysis. We used publicly available genome-wide association study datasets to identify the single nucleotide polymorphisms associated with both RA and AS. We then applied statistical methods, including inverse variance weighting, MR-Egger regression, and weighted medians, to assess the causal effects between the 2 diseases. This study provides evidence through two-sample Mendelian randomization analysis, suggesting that RA may be an independent risk factor for AS. This highlights the role of immune modulation in the genetic overlap between The and AS, offering new perspectives for future research on immune disease mechanisms, and potential clinical prevention and treatment strategies.