甘油三酯葡萄糖-相对脂肪质量指数与阻塞性睡眠呼吸暂停风险之间的关联：一项来自NHANES的横断面研究
Association between triglyceride glucose-relative fat mass index and obstructive sleep apnea risk: A cross-sectional study from NHANES.
文献信息
| PMID | 42937790 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Yunzhou Zheng |
| 作者单位 | Clinical Laboratory, Bethune International Peace Hospital, Shijiazhuang, People's Republic of China. |
| 期刊 | Medicine |
| SCI 分区 | Q2 |
| IF | 2.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
甘油三酯葡萄糖（TyG）指数与胰岛素抵抗和阻塞性睡眠呼吸暂停（OSA）相关，而相对脂肪质量（RFM）指数与肥胖和OSA相关。然而，甘油三酯葡萄糖-相对脂肪质量（TyG-RFM）指数与OSA之间的关系在美国人群中研究较少。本研究旨在探讨TyG-RFM指数与OSA患病率之间的关联。本横断面分析的数据来自2005至2008年以及2015至2018年周期的美国国家健康与营养调查，纳入年龄≥20岁的参与者。采用加权多变量logistic回归和限制性立方样条检验TyG-RFM指数与OSA之间的关系。进行分层分析和敏感性分析以检验该关联的一致性。在7283名参与者中，平均年龄为46.9岁（标准差=16.7）岁，48.7%为男性。其中，3616人表现出OSA症状。拟合曲线显示TyG-RFM指数与OSA之间呈线性正相关（非线性P=0.292）。在完全调整模型中，TyG-RFM指数每增加10个单位与OSA风险升高4%相关（比值比，1.04；95%置信区间，1.02-1.06）。按五分位数分析时，最高五分位参与者相比最低五分位者OSA的比值比高95%（比值比，1.95；95%置信区间，1.29-2.95）。分层分析和敏感性分析证实了主要结果的稳定性。本横断面研究表明，TyG-RFM指数与美国成人OSA风险相关。这些结果可能有助于OSA风险分层和早期筛查。
英文摘要
The triglyceride glucose (TyG) index is correlated with insulin resistance and obstructive sleep apnea (OSA), whereas the relative fat mass (RFM) index is linked to obesity and OSA. However, the relationship between the triglyceride glucose-relative fat mass (TyG-RFM) index and OSA has been less studied in the US population. This research was designed to investigate the association between the TyG-RFM index and OSA prevalence. Data for this cross-sectional analysis were drawn from the 2005 to 2008 and 2015 to 2018 cycles of the National Health and Nutrition Examination Survey, including participants aged ≥20 years. Weighted multivariate logistic regression and restricted cubic splines were employed to examine the relationship between the TyG-RFM index and OSA. Stratified and sensitivity analyses were undertaken to test the consistency of the association. Of the 7283 participants, the mean age was 46.9 (standard deviation = 16.7) years, and 48.7% were male. Among them, 3616 individuals exhibited symptoms of OSA. The fitted curve demonstrated a linear positive relationship between the TyG-RFM index and OSA (P for nonlinearity = 0.292). In the fully adjusted model, each 10-unit increase in the TyG-RFM index was associated with a 4% higher OSA risk (odds ratio, 1.04; 95% confidence interval, 1.02-1.06). When analyzed by quintiles, participants in the highest quintile had 95% greater odds of OSA compared with those in the lowest quintile (odds ratio, 1.95; 95% confidence interval, 1.29-2.95). Stratified and sensitivity analyses confirmed the stability of the primary results. This cross-sectional research showed that the TyG-RFM index was associated with OSA risk among US adults. These results may aid in OSA risk stratification and early screening.