Article record

Bet v 1过敏原是比利时花粉过敏患者疾病的主要驱动因素。

Bet v 1 Allergen Is the Main Driver of Disease in Patients with Pollen Allergy in Belgium.

临床研究鼻科IF 6.6Q2

文献信息

PMID	42929879
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Françoise Pirson 查看其他 6 位作者 Esmeralda Fraille Lopez；Cloé Hupin；Carine Sohy；Bertrand Bearzatto；Marylène Lecocq；Charles Pilette
作者单位	Department of Pulmonary Medicine, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium. 查看其他 9 条单位信息 Allergy Center Saint-Luc, Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium.；Lung, Nose and Skin Research Unit (LUNS), Institute of Experimental and Clinical Research (IREC), Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium.；Faculty of Medicine, Campus of Woluwé-Saint-Lambert, Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium.；Dispens's Soins, 6200 Châtelet, Belgium.；Department of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.；Department of Otgorhinolaryngology, Hôpital Delta, 1160 Brussels, Belgium.；Department of Pulmonary Medicine, University Hospital Center UCL Namur, Godinne Site, 5530 Yvoir, Belgium.；Allergy Center Godinne, University Hospital Center UCL Namur, Godinne Site, 5330 Yvoir, Belgium.；Experimental and Clinical Research Institute (IREC), Center for Applied Molecular Technologies, Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium.
期刊	Cells
SCI 分区	Q2
IF	6.6
研究类型	临床研究 · 临床
所属专科	鼻科

中文摘要

背景： 对桦树花粉致敏并同时致敏Bet v 1和Bet v 2过敏原的患者，出现更频繁和更严重的呼吸道或植物相关食物过敏症状（PFASs）。本研究分析了Bet v 1和profilin致敏在比利时花粉过敏患者临床表型中的相关性。方法：10例对桦树花粉过敏（BPA）、31例对草花粉过敏（GPA）和33例对两种花粉均过敏（MPA）且伴有鼻炎-结膜炎伴/不伴哮喘（ARRC）的患者，通过问卷、皮肤点刺试验和特异性IgE检测进行评估。结果：半数GPA同时致敏桦树花粉，且无BPA对profilin致敏。哮喘和花粉相关食物过敏综合征（PFAS）的患病率在BPA中高于MPA或GPA，且哮喘性BPA中PFAS严重程度更高。伴有PFAS的GPA更常对Bet v 1致敏，且rBet v 1-IgE水平更高。结论：无论Bet v 1-IgE和症状严重程度如何，PFAS患病率以及鼻炎和PFAS持续时间在profilin多致敏GPA中较单致敏和未致敏GPA呈增加趋势。

英文摘要

Birch pollen-sensitized patients co-sensitized to Bet v 1 and Bet v 2 allergens present more frequent and severe respiratory or plant-related food allergy symptoms (PFASs). This study analyzed the relevance of Bet v 1 and profilin sensitization in the clinical phenotype of pollen-allergic patients in Belgium. Ten patients allergic to birch pollen (BPA), 31 to grass pollen (GPA) and 33 to both pollens (MPA), with rhino-conjunctivitis with/without asthma (ARRC), were evaluated by means of questionnaire, skin-prick tests and specific IgE assays. Half of GPA were co-sensitized to birch pollen, and no BPA were sensitized to profilin. The prevalence of asthma and pollen-related food allergy syndrome (PFAS) was higher in BPA than in MPA or GPA, with a higher severity of PFAS in asthmatic BPA. GPA with PFAS were more frequently sensitized to Bet v 1, with higher levels of rBet v 1-IgE. The prevalence of PFAS, together with the duration of rhinitis and PFAS tended to increase in profilin-polysensitized vs. mono- and un-sensitized GPA, regardless of Bet v 1-IgE and the severity of symptoms.