前庭神经鞘瘤患者接受伽玛刀与基于直线加速器的放射外科治疗的结果比较：一项回顾性研究。
Outcomes for Patients With Vestibular Schwannomas Treated With Gamma Knife Versus Linear Accelerator-Based Radiosurgery: A Retrospective Review.
文献信息
| PMID | 42927347 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2027 |
| 作者 | Taylor Corriher |
| 作者单位 | Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia. |
| 期刊 | Advances in radiation oncology |
| SCI 分区 | Q2 |
| IF | 2.6 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 既往研究报告显示，接受伽玛刀放射外科（GKRS）或基于直线加速器（LINAC）的放射外科治疗的前庭神经鞘瘤（VS）患者局部控制良好；然而，缺乏对两种方法生活质量结局的直接比较。我们评估了接受GKRS与LINAC治疗的VS患者放疗后生活质量结局和局部控制的差异。
方法： 在这项多中心分析中，我们回顾性审查了接受GKRS或LINAC治疗的VS病例，并比较了治疗后临床结局，包括肿瘤控制以及新发眩晕、步态障碍、面瘫和耳鸣。进行了描述性统计，并使用χ2检验评估组间差异。进行了单因素和多因素分析，以评估与临床结局发生的相关性。
结果： 我们的分析纳入了36例接受GKRS治疗的患者和49例接受LINAC治疗的患者。所有患者均接受单次分割放射外科治疗。LINAC与GKRS在治疗后眩晕、步态障碍或面瘫的发生方面无统计学显著差异，耳鸣的发生也无临床显著差异。所有患者的局部控制率为98.8%，两组间肿瘤控制无统计学显著差异。
结论： 该分析显示，对于VS，GKRS与基于LINAC的放射外科在新发眩晕、步态障碍、耳鸣和面瘫方面发生率相当，支持这些治疗方法的可互换性。需要前瞻性数据来进一步比较这些治疗方法。
英文摘要
PURPOSE: Prior studies have reported favorable local control for patients with vestibular schwannomas (VS) treated with Gamma Knife radiosurgery (GKRS) or linear accelerator (LINAC)-based radiosurgery; however, direct comparisons of quality-of-life outcomes with each approach are lacking. We assessed differences in quality-of-life outcomes and local control after radiation therapy for patients with VS treated with GKRS versus LINAC.
METHODS AND MATERIALS: In this multicenter analysis, we retrospectively reviewed VS cases treated with either GKRS or LINAC and compared posttreatment clinical outcomes, including tumor control and new development of vertigo, gait disturbance, facial palsy, and tinnitus. Descriptive statistics were performed, and χ2 was used to assess intergroup differences. Univariate and multivariate analyses were performed to assess associations with the development of clinical outcomes.
RESULTS: Thirty-six patients treated with GKRS and 49 patients treated with LINAC were included in our analysis. All patients were treated with single-fraction radiosurgery. There was no statistically significant difference between LINAC and GKRS in the development of vertigo, gait disturbance, or facial palsy after treatment, and no clinically significant difference in the development of tinnitus. Local control was 98.8% across all patients, with no statistically significant difference in tumor control between groups.
CONCLUSIONS: This analysis showed comparable rates of new vertigo, gait disturbance, tinnitus, and facial palsy with GKRS and LINAC-based radiosurgery for VS, supporting the interchangeability of these treatment approaches. Prospective data are needed to further compare these treatment approaches.