Article record

前哨淋巴结引导下口腔舌鳞状细胞癌术后放疗的调整：一项回顾性剂量学与NTCP建模研究

Sentinel lymph node-guided modification of postoperative radiotherapy in oral tongue squamous cell carcinoma: a retrospective dosimetric and NTCP modelling study.

临床研究鼻科IF 3.4Q1

文献信息

PMID	42927216
原文	在 PubMed 查看原文 ↗
发表日期	2027
作者	Einar Björgvinsson 查看其他 9 位作者 Aeneas Kolev；Eva Onjukka；Mattias Hedman；Åsa Carlsson Tedgren；Lars Södergren；Signe Friesland；Gregori Margolin；Lars-Olaf Cardell；Michael Gubanski
作者单位	Department of Head and Neck Oncology, Karolinska University Hospital, 17164 Stockholm, Sweden. 查看其他 5 条单位信息 Department of Oncology-Pathology, Karolinska Institution, 171 77 Stockholm, Sweden.；Department of Head and Neck Surgery, Karolinska University Hospital, 17164 Stockholm, Sweden.；Department of Science, Intervention and Technique, Karolinska Institution, 141 52 Stockholm, Sweden.；Department of Nuclear Medicine, Karolinska University Hospital, 17164 Stockholm, Sweden.；Department of Radiation Therapy, Karolinska University Hospital, 17164 Stockholm, Sweden.
期刊	Clinical and translational radiation oncology
SCI 分区	Q1
IF	3.4
研究类型	临床研究 · 临床
所属专科	鼻科

中文摘要

•前哨淋巴结活检（SLNB）在近半数口腔舌鳞状细胞癌（OTSCC）患者中发现了超出标准选择性照射范围的淋巴引流。
•SLNB可能指导个体化术后放疗，包括在部分患者中省略对侧颈部照射。
•调整后的计划显著降低了口干症和吞咽困难的估计正常组织并发症概率（NTCP）。
•SLNB可能支持OTSCC选择性颈部照射的个体化降阶梯与优化。

英文摘要

•SLNB identified lymphatic drainage beyond standard elective volumes in nearly half of OTSCC patients.•SLNB may guide individualized postoperative radiotherapy, including omission of contralateral neck irradiation in selected patients.•Adapted plans significantly reduced estimated NTCPs for xerostomia and dysphagia.•SLNB may support individualized de-escalation and optimization of elective neck irradiation in OTSCC.