卡塔尔化脓性脑脓肿：一项全国性回顾性观察研究
Pyogenic brain abscesses in Qatar: A national retrospective observational study.
文献信息
| PMID | 42927205 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Sabeen Zara |
| 作者单位 | Division of Infectious Diseases, Department of Internal Medicine, Communicable Disease Center, Hamad Medical Corporation, Doha, Qatar. |
| 期刊 | IJID regions |
| SCI 分区 | Q3 |
| IF | 2.2 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 化脓性脑脓肿是一种危及生命的颅内感染，需要及时诊断以及协调的内科-外科治疗。来自海湾地区的区域数据仍然匮乏。
方法： 我们回顾性分析了2015年至2023年间在卡塔尔哈马德医疗集团根据临床表现和神经影像学发现诊断为化脓性脑脓肿的成年患者的人口学、临床、微生物学、管理和结局数据。结局采用格拉斯哥结局量表（GOS）分类为良好（GOS 4-5）或不良（GOS 1-3）。
结果： 共纳入48例患者；41/48（85%）为男性，中位年龄为34岁。常见合并症和易感条件包括糖尿病、中耳炎/乳突炎和鼻窦炎。35/48（73%）患者建立了微生物学诊断。最常分离出的病原体为咽峡炎链球菌群、金黄色葡萄球菌和肺炎克雷伯菌。38/48（79%）患者接受了手术干预，35/48（73%）获得良好结局。在未调整分析中，近期神经外科手术和革兰阴性菌感染在结局不良患者中更常见。这些患者基线格拉斯哥昏迷量表评分较低，且更常表现为意识改变。
结论： 在未调整分析中，接受手术干预的患者和就诊时意识保留的患者中良好结局更常见。然而，不能推断因果关系。
英文摘要
OBJECTIVES: Pyogenic brain abscess is a life-threatening intracranial infection requiring timely diagnosis and coordinated medical-surgical management. Regional data from the Gulf area remains scarce.
METHODS: We retrospectively analyzed demographic, clinical, microbiological, management, and outcome data from adults diagnosed with pyogenic brain abscess based on clinical presentation and neuroimaging findings at Hamad Medical Corporation, Qatar, between 2015 and 2023. Outcomes were categorized using the Glasgow Outcome Scale (GOS) as favorable (GOS 4-5) or unfavorable (GOS 1-3).
RESULTS: Forty-eight patients were included; 41/48 (85%) were male, with a median age of 34 years. Common comorbidities and predisposing conditions included diabetes mellitus, otitis/mastoiditis, and sinusitis. A microbiological diagnosis was established in 35/48 (73%) patients. The most frequently isolated pathogens were the Streptococcus anginosus group, Staphylococcus aureus, and Klebsiella pneumoniae. Surgical intervention was performed in 38/48 (79%) patients, and 35/48 (73%) achieved a favorable outcome. In unadjusted analyses, recent neurosurgical procedures and Gram-negative infections were more frequent among patients with unfavorable outcomes. These patients had lower baseline Glasgow Coma Scale scores and more frequently presented with altered consciousness.
CONCLUSION: In unadjusted analyses, favorable outcomes were more frequent among patients who underwent surgical intervention and those presenting with preserved consciousness. However, causality cannot be inferred.