子痫前期孕妇的睡眠模式与睡眠障碍：系统综述与荟萃分析
Sleep patterns and sleep disorders in pregnant women with preeclampsia: a systematic review and meta-analysis.
文献信息
| PMID | 42923919 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Rebeca Lundii Oliveira Pereira |
| 作者单位 | Universidade Federal de São Paulo Escola Paulista de Medicina São PauloSP Brazil Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil. |
| 期刊 | Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia |
| SCI 分区 | Q3 |
| IF | 1.9 |
| 研究类型 | 综述 Meta · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 子痫前期（PE）是一种妊娠期高血压疾病，其危险因素多样且认识不足。此期间的激素变化会影响睡眠，从而提出睡眠障碍是否可能与PE相关的问题。本综述旨在调查被诊断为PE的孕妇中睡眠障碍的患病率。
方法： 我们纳入了通过任何方法评估睡眠的观察性研究和临床试验。排除标准为未评估睡眠的PE研究、系统综述、社论、动物研究以及无法获取全文的研究。研究通过Virtual Health Library、MEDLINE和Embase检索，使用描述词“preeclampsia”和“sleep”，并辅以手工检索。最后一次检索于2024年12月10日进行。筛选和数据提取由两名评价者独立完成。使用Joanna Briggs Institute清单评估偏倚风险。采用随机效应模型将患病率合成为比例，并计算95%置信区间（CIs）。
结果： 从最初识别的2,075项研究中纳入21项研究。PE中睡眠障碍的合并患病率为46%（95% CI [0,19 - 0,76]），p=0,823。分层分析识别出两个类别：定性睡眠障碍，患病率为50%（95% CI [0.31-0.70]）；以及睡眠呼吸障碍，患病率为43%（95% CI [0.10-0.83]）。
讨论： 本荟萃分析发现子痫前期中睡眠障碍的估计患病率为46%；然而，由于极端异质性和未控制的偏倚风险，证据质量极低（GRADE）。PROSPERO：CRD42024557766。
英文摘要
OBJECTIVE: Preeclampsia (PE) is a hypertensive disorder of pregnancy with diverse and poorly understood risk factors. Hormonal changes during this period affect sleep, raising the question of whether sleep disturbances may be related to PE. This review aimed to investigate the prevalence of sleep disturbances among pregnant women diagnosed with PE.
METHODS: We included observational studies and clinical trials assessing sleep by any method. Exclusion criteria were studies on PE without sleep assessment, systematic reviews, editorials, animal studies, and unavailable full texts. Studies were retrieved from Virtual Health Library, MEDLINE and Embase using the descriptors "preeclampsia" and "sleep" with additional manual searches. The last search was conducted on December 10, 2024. Screening and data extraction were performed independently by two reviewers. Risk of bias was assessed using the Joanna Briggs Institute checklist. Random-effects models were used to synthesize prevalence as proportions with 95% confidence intervals (CIs).
RESULTS: Twenty-one studies were included from 2,075 initially identified. The pooled prevalence of sleep disturbances in PE was 46% (95% CI [0,19 - 0,76]), p=0,823. Stratified analysis identified two categories: qualitative disturbances, with prevalence of 50% (95% CI [0.31-0.70]); and sleep-disordered breathing with prevalence of 43% (95% CI [0.10-0.83]).
DISCUSSION: This meta-analysis found an estimated 46% prevalence of sleep disturbances in preeclampsia; however, the evidence is of very low quality (GRADE), due to extreme heterogeneity and uncontrolled risk of bias.PROSPERO: CRD42024557766.