Article record

台湾鼻腔鼻窦恶性肿瘤（2009-2019）：组织学分布、总生存率及血液系统与非血液系统肿瘤的时间趋势

Sinonasal Malignancies in Taiwan (2009-2019): Histologic Distribution, Overall Survival, and Temporal Trends in Hematological Versus Nonhematological Tumors.

临床研究鼻科IF 2.1Q2

文献信息

PMID	42923043
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Chi-Hsien Wu 查看其他 2 位作者 Ching-Heng Lin；Kai-Li Liang
作者单位	Department of Medical Education Taichung Veterans General Hospital Taichung Taiwan. 查看其他 7 条单位信息 Department of Public Health College of Medicine, Fu Jen Catholic University New Taipei City Taiwan.；Department of Industrial Engineering and Enterprise Information Tunghai University Taichung Taiwan.；Institute of Public Health and Community Medicine Research Center National Yang Ming Chiao Tung University Taipei Taiwan.；Department of Otolaryngology Taichung Veterans General Hospital Taichung Taiwan.；School of Medicine, National Yang Ming Chiao Tung University Taipei Taiwan.；School of Medicine, Chung Shan Medical University Taichung Taiwan.；Department of Post-Baccalaureate Medicine College of Medicine, National Chung Hsing University Taichung Taiwan.
期刊	Laryngoscope investigative otolaryngology
SCI 分区	Q2
IF	2.1
研究类型	临床研究 · 临床
所属专科	鼻科

中文摘要

背景： 鼻腔鼻窦恶性肿瘤罕见且组织学多样，来自亚洲的基于人群的数据有限。本研究调查了台湾的组织学分布、与总生存期（OS）相关的因素以及生存率的时间模式。
方法： 这项回顾性基于人群的研究使用了台湾全民健康保险研究数据库和台湾癌症登记处的关联数据。纳入2009年至2019年间诊断为侵袭性鼻腔或鼻旁窦恶性肿瘤的成人。分别对血液系统和非血液系统恶性肿瘤使用多变量Cox回归分析评估与OS相关的因素。
结果： 在1494例患者中，718例（48.1%）患有血液系统恶性肿瘤，776例（51.9%）患有非血液系统恶性肿瘤。鳞状细胞癌在非血液系统恶性肿瘤中占主导地位，而在血液系统恶性肿瘤中，T细胞和NK/T细胞淋巴瘤比成熟B细胞淋巴瘤更常见。年龄增长与两组死亡风险升高相关。在非血液系统恶性肿瘤中，记录的手术操作与较低的死亡风险相关（调整风险比[aHR]，0.52；95% CI，0.42-0.66），而化疗与较高的风险相关（aHR，1.81；95% CI，1.36-2.39）。在血液系统恶性肿瘤中，2015-2019年诊断与2009-2014年相比死亡风险较低（aHR，0.76；95% CI，0.60-0.96）。
结论： 台湾的鼻腔鼻窦恶性肿瘤显示出独特的组织学和生存模式。T细胞和NK/T细胞肿瘤占主导地位以及近期生存率改善，突显了台湾血液系统鼻腔鼻窦恶性肿瘤的重要流行病学特征。

英文摘要

BACKGROUND: Sinonasal malignancies are rare and histologically diverse, with limited population-based data from Asia. This study investigated the histologic distribution, factors associated with overall survival (OS), and temporal survival patterns in Taiwan.
METHODS: This retrospective population-based study used linked data from the Taiwan National Health Insurance Research Database and Taiwan Cancer Registry. Adults with invasive nasal cavity or paranasal sinus malignancies diagnosed between 2009 and 2019 were included. Factors associated with OS were evaluated using multivariable Cox regression analysis separately for hematological and nonhematological malignancies.
RESULTS: Among 1494 patients, 718 (48.1%) had hematological malignancies, and 776 (51.9%) had nonhematological malignancies. Squamous cell carcinoma predominated among nonhematological malignancies, whereas T-cell and NK/T-cell lymphomas were more common than mature B-cell lymphomas among hematological malignancies. Increasing age was associated with a higher hazard of death in both groups. In nonhematological malignancies, recorded surgical procedures were associated with a lower hazard of death (adjusted hazard ratio [aHR], 0.52; 95% CI, 0.42-0.66), whereas chemotherapy was associated with a higher hazard (aHR, 1.81; 95% CI, 1.36-2.39). In hematological malignancies, diagnosis during 2015-2019 was associated with a lower hazard of death than during 2009-2014 (aHR, 0.76; 95% CI, 0.60-0.96).
CONCLUSION: Sinonasal malignancies in Taiwan showed distinct histologic and survival patterns. The predominance of T-cell and NK/T-cell neoplasms and improved survival in the more recent period highlight important epidemiological characteristics of hematological sinonasal malignancies in Taiwan.
LEVEL OF EVIDENCE: 3.