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多通道光学人工耳蜗实现频谱上可区分的听觉活动

Multichannel optical cochlear implants enable spectrally distinct auditory activity.

基础研究耳科IF 9.6Q1

文献信息

PMID42918880
原文在 PubMed 查看原文 ↗
发表日期2026
作者Niels Albrecht
查看其他 12 位作者

Elisabeth Koert；Anna Vavakou；Lennart Roos；Lukasz Jablonski；Juan Pablo Marcoleta；Josep Cardona Audi；Jette Alfken；Eric Klein；Patrick Ruther；Thomas Mager；Kathrin Kusch；Tobias Moser

作者单位Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37075, Göttingen, Germany.
查看其他 16 条单位信息

Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen, 37073, Göttingen, Germany.；Else Kröner-Fresenius Center for Optogenetic Therapies, University Medical Center Göttingen, 37075, Göttingen, Germany.；Collaborative Research Center SFB 1690 "Disease mechanisms and functional restoration of sensory and motor systems", University of Göttingen, 37073, Göttingen, Germany.；Department of Otolaryngology, University Medical Center Göttingen, 37075, Göttingen, Germany.；Computational Neuroscience and Neuroengineering Junior Research Group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, 37077, Göttingen, Germany.；Auditory Neuroscience and Optogenetics laboratory, German Primate Center, 37077, Göttingen, Germany.；Institute for X-ray Physics, University of Göttingen, 37077, Göttingen, Germany.；Department of Microsystems Engineering (IMTEK), University of Freiburg, 79110, Freiburg, Germany.；BrainLinks-BrainTools Center, University of Freiburg, 79119, Freiburg, Germany.；Advanced Optogenes Group, Institute for Auditory Neuroscience, University Medical Center Göttingen, 37075, Göttingen, Germany.；Functional Auditory Genomics Group, Auditory Neuroscience and Optogenetics laboratory, German Primate Center, 37077, Göttingen, Germany.；Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37075, Göttingen, Germany. tmoser@gwdg.de.；Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Göttingen, 37073, Göttingen, Germany. tmoser@gwdg.de.；Else Kröner-Fresenius Center for Optogenetic Therapies, University Medical Center Göttingen, 37075, Göttingen, Germany. tmoser@gwdg.de.；Collaborative Research Center SFB 1690 "Disease mechanisms and functional restoration of sensory and motor systems", University of Göttingen, 37073, Göttingen, Germany. tmoser@gwdg.de.；Auditory Neuroscience and Synaptic Nanophysiology Group, Max-Planck-Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany. tmoser@gwdg.de.

期刊EMBO molecular medicine
SCI 分区Q1
IF9.6
研究类型基础研究 · 基础／转化
所属专科耳科

中文摘要

当听力丧失时，人工耳蜗（CIs）可恢复听觉感知。然而，频谱信息的编码仍是一个瓶颈，因为每个电极都会广泛激活听神经。由于光在空间上更容易被限制，光学（o）CIs提供了一种替代方案。在此，我们将强效通道视紫红质ChReef在螺旋神经节神经元（SGNs）中的表达与包含5-10个绿色LED的oCIs相结合，应用于沙鼠。这一组合使得能够在可转化的能量范围内，系统比较单个oCI通道对强度和频谱信息的编码与声刺激和电刺激的差异。下丘（ICC）记录显示，ChReef使SGN的光敏感性与LED辐射通量相匹配：ICC活动的阈值<200 nJ，并达到与51 dB SPL纯音相当的最大值。多通道oCIs实现了按音调定位有序、频谱上可区分的刺激，比电刺激更接近声刺激。一些LED在较高强度下引起多个频谱峰值。对ICC活动的线性判别分析表明，光刺激比电刺激具有更好的通道可区分性。总之，µJ-oCI刺激相比最先进的电刺激实现了更好的频谱分辨率。

英文摘要

When hearing fails, cochlear implants (CIs) restore auditory perception. Yet, coding of spectral information remains a bottleneck because each electrode broadly activates the auditory nerve. As light can be more conveniently confined in space, optical (o)CIs present an alternative. Here, we combined expression of the potent channelrhodopsin ChReef in spiral ganglion neurons (SGNs) with oCIs comprising 5-10 green LEDs in gerbils. This combination enabled systematic comparison of encoding intensity and spectral information by individual oCI channels to acoustic and electrical stimulation within a translationally feasible energy range. Recordings from the inferior colliculus (ICC) showed that ChReef aligned SGN light sensitivity with LED radiant fluxes: ICC activity had thresholds <200 nJ and reached a maximum equivalent to that achieved with 51 dB SPL pure tones. Multichannel oCIs enabled tonotopically ordered, spectrally distinct stimulation that more closely resembled acoustic stimulation than did electrical stimulation. Some LEDs elicited multiple spectral peaks at higher intensities. Linear discriminant analysis of ICC activity indicated improved channel discriminability for optical over electrical stimulation. In summary, µJ-oCI-stimulation achieves improved spectral resolution over state-of-the-art electrical stimulation.