良性阵发性位置性眩晕中丘脑亚区的功能连接与白质微结构改变
Functional Connectivity and White Matter Microstructural Alterations of Thalamic Subregions in Benign Paroxysmal Positional Vertigo.
文献信息
| PMID | 42918585 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Ke Yang |
| 作者单位 | Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. |
| 期刊 | Brain research bulletin |
| SCI 分区 | Q2 |
| IF | 4.2 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 良性阵发性位置性眩晕（BPPV）是一种常见的周围性前庭疾病。尽管丘脑是前庭通路中的关键节点，但其在BPPV中枢调控中的作用仍不清楚。本研究旨在探讨BPPV患者丘脑的功能和结构改变。
方法： 研究招募了52例BPPV患者和52名年龄、性别匹配的健康志愿者。采用基于种子点的分析探讨患者组丘脑亚区与全脑之间的功能连接（FC）改变。随后采用概率纤维追踪分析功能改变脑区的白质结构差异。此外，进行相关分析以探讨异常影像学指标与临床量表之间的关系。
结果： 与对照组相比，BPPV患者某些丘脑亚区与特定大脑皮质之间的FC增加，且各向异性分数（FA）值升高。作为验证性发现，BPPV患者吻侧颞叶丘脑与小脑之间表现为FC降低但结构连接增加。此外，吻侧颞叶丘脑-小脑束的FA值与事件影响量表评分相关。中介分析显示，情绪困扰介导了眩晕与吻侧颞叶丘脑-小脑束FA之间的关系。
结论： 在BPPV中，丘脑亚区与某些大脑皮质表现出协同的功能和结构增强，而在小脑中观察到一种明显的分离模式。这种差异化的重组可能表征了BPPV早期的神经过程。
英文摘要
OBJECTIVE: Benign Paroxysmal Positional Vertigo (BPPV) is a common peripheral vestibular disorder. Although the thalamus serves as a key node in vestibular pathways, its role in the central regulation of BPPV remains unclear. This study aimed to explore the functional and structural alterations of thalamus in patients with BPPV.
METHODS: The study recruited 52 BPPV patients and 52 age- and gender-matched healthy volunteers. Seed-based analysis was used to explore functional connectivity (FC) alterations between thalamic subregions and the whole brain in patient group. Probabilistic fiber tracking was then employed to analyze white matter structural differences in brain regions with functional alterations. Additionally, correlation analysis was conducted to investigate the relationship between abnormal imaging metrics and clinical scales.
RESULTS: Compared to controls, patients with BPPV exhibited increased FC and higher fractional anisotropy (FA) values of some thalamic subregions to certain cerebral cortices. As a confirmatory finding, decreased FC but increased structural connectivity was displayed between the rostral temporal thalamus and cerebellum in BPPV. Furthermore, the FA value of the rostral temporal thalamus-cerebellar tract showed a correlation with the score of the impact of event scale. The mediation analysis showed emotional distress mediated the relationship between vertigo and FA of the rostral temporal thalamus-cerebellar tract.
CONCLUSIONS: In BPPV, the thalamic subregions and certain cerebral cortices exhibit synergistic functional and structural enhancement, whereas a distinct dissociation pattern is observed in the cerebellum. This differentiated reorganization may characterize the neural process in the early stage of BPPV.