能量调整儿童膳食炎症指数与学龄儿童听力损失的关联：NHANES 2005-2020横断面研究
Association of the energy-adjusted children's dietary inflammatory index with hearing loss in school-aged children: A cross-sectional study of NHANES 2005-2020.
文献信息
| PMID | 42913183 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Lei Lei |
| 作者单位 | Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital of Sichuan University, 37 Guoxue Hang, Wuhou District, Chengdu, Sichuan, 610041, China; Nemours Biomedical Research, Nemours Children's Health, Delaware, 1600 Rockland Rd., Wilmington, DE, 19803, USA. Electronic address: leilei@wchscu.cn. |
| 期刊 | American journal of otolaryngology |
| SCI 分区 | Q2 |
| IF | 1.8 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 听力损失（HL）与促炎饮食相关。本研究评估了HL与能量调整儿童膳食炎症指数（EC-DII）之间的关联，EC-DII是对儿童膳食营养素炎症性的综合评估。
方法： 本横断面研究分析了2005年至2020年国家健康与营养调查（NHANES）中6至14岁、完成听力测试和24小时膳食评估的儿童数据。HL定义为言语频率（SFHL，0.5、1、2和4 kHz纯音平均听阈）和高频（HFHL，3、4和6 kHz纯音平均听阈）听阈≥16 dB。计算每位参与者的EC-DII评分（按每1000 kcal能量调整以校正总能量摄入差异），并分为四分位I-IV组。采用多变量logistic回归模型评估关联，统计显著性以p值、比值比（OR）和95%置信区间（CI）报告。
结果： 在调整回归分析模型中，EC-DII评分与HFHL风险增加显著相关（OR=1.16，CI=1.06-1.27，p=0.001）及SFHL风险增加显著相关（OR=1.16，CI=1.04-1.30，p=0.009）。EC-DII第四四分位（最高膳食炎症水平）与HFHL风险增加相关（OR=1.33；CI 1.09-1.6，p=0.004）及SFHL风险增加相关（OR=1.31，CI 1.06-1.63，p=0.017）。
结论： 本研究表明，较高的EC-DII评分以及最高膳食炎症水平第四四分位与HL显著相关。由于研究的横断面性质，无法建立因果推断和时间关系。因此，由EC-DII量化的促炎饮食对儿童HL发生的潜在贡献需要通过前瞻性队列研究和设计良好的临床试验进一步研究。
英文摘要
OBJECTIVE: Hearing loss (HL) has been linked to a pro-inflammatory diet. This study evaluated the association between HL and the Energy-Adjusted Children's Dietary Inflammatory Index (EC-DII), a comprehensive inflammatory assessment of dietary nutrients in children.
METHODS: This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) for children aged 6 to 14 years who completed both audiometric testing and 24-h dietary assessments between 2005 and 2020. HL was defined as audiometric thresholds ≥16 dB on the pure-tone average of 0.5, 1, 2, and 4 kHz for speech frequency (SFHL) and 3, 4, and 6 kHz for high frequency (HFHL). EC-DII scores (Energy-adjusted per 1000 kcal to account for differences in total energy intake) were calculated for each participant and classified into quartile I-IV. The association was evaluated using multivariable logistic regression models, with statistical significance reported as p-values, odds ratios (ORs), and 95% confidence intervals (CIs).
RESULTS: In adjusted regression analysis model, EC-DII scores were significantly associated with an increased risk of HFHL (OR = 1.16, CI = 1.06-1.27, p = 0.001) and SFHL (OR = 1.16, CI = 1.04-1.30, p = 0.009). EC-DII quartile IV, the highest level of dietary inflammation, was associated with an increased risk of HFHL (OR = 1.33; CI 1.09-1.6, p = 0.004) and SFHL (OR = 1.31, CI 1.06-1.63, p = 0.017).
CONCLUSION: The study demonstrated that higher EC-DII scores, as well as the highest dietary inflammatory level quartile IV, were significantly associated with HL. Due to the cross-sectional nature of the study, causal inferences and temporal relationships could not be established. Therefore, the potential contribution of a pro-inflammatory diet, as quantified by the EC-DII, to the development of HL in children requires further investigation through prospective cohort studies and well-designed clinical trials.