唾液刺激产品的功效、缓冲能力及动态变化

文献信息

中文摘要

背景： 唾液在维持口腔健康与完整性的同时，也在口腔内构成复杂的交响乐。唾液的润滑特性不仅使说话和吞咽更容易，还通过酶解过程分解脂质和碳水化合物，促进消化。
目的： 在随机对照交叉试验中比较六种不同唾液刺激产品的功效、缓冲能力及时间动态变化。
方法与材料： 纳入12名健康成人，每人在不同日期测试六种产品（薄荷口香糖、Salivin、Jaw Peer中号、Jaw Peer大号、Jaw Peer小号和对照）。在基线和产品使用后1、3和6分钟测量刺激唾液分泌率、缓冲能力和pH。产品间及同一产品不同时间点的比较采用双因素方差分析，随后进行Tukey事后检验。统计学显著性水平设定为p 0.05。
结果： 薄荷口香糖和Jaw Peer大号产生的刺激唾液分泌率最高。Jaw Peer产品的缓冲能力下降最大，而Salivin的缓冲能力随时间保持稳定。所有产品的缓冲能力均观察到显著的时间变化。产品间非刺激唾液分泌率未发现显著差异。
结论： 非刺激唾液流率产品对唾液流率、缓冲能力和时间动态变化表现出不同影响。产品选择应根据患者偏好、具体临床需求和作用持续时间进行个体化，尽管与单独咀嚼石蜡相比，这些唾液刺激产品的改善非常有限。

英文摘要

BACKGROUND: Saliva maintains the health and integrity of the oral cavity while composing a complex symphony within it. Saliva's lubricating qualities not only make talking and swallowing easier, but also promote digestion by breaking down lipids and carbohydrates through enzymatic processes.
AIM: To compare the efficacy, buffering capacity and temporal dynamics of six different saliva-stimulating products in a randomised controlled crossover trial.
METHODS AND MATERIALS: Twelve healthy adults were enrolled, each testing six products (chewing gum with mint, Salivin, Jaw Peer medium, Jaw Peer large, Jaw Peer small and control) on separate days. Stimulated saliva secretion rate, buffering capacity, and pH were measured at baseline and at 1, 3 and 6 min following product use. Comparison between products and different time points for the same product was performed using two-way ANOVA followed by Tukey's post hoc test. A significance level of p 0.05 was applied for statistical significance.
RESULTS: Chewing gum with mint and Jaw Peer large produced the highest stimulated saliva secretion rates. The Jaw Peer product showed the greatest decrease in buffering capacity, while Salivin showed stable buffering capacity over time. Significant temporal variations in buffering capacity were observed for all products. No significant differences were found in unstimulated salivary secretion rate between products.
CONCLUSIONS: Unstimulated salivary flow rate products exhibit different effects on salivary flow, buffering capacity, and temporal dynamics. Choice of product should be individualised based on patient preferences, specific clinical needs and duration of action, although very limited improvement was noticed with these saliva-stimulating products compared to chewing paraffin alone.