致编辑的信：关于“小题大做：间歇性禁食与卒中后神经保护”
EXPRESS: Letter to the Editor Regarding "Much ado about eating: Intermittent fasting and post-stroke neuroprotection".
文献信息
| PMID | 42902476 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Guilherme Bezerra Carneiro |
| 作者单位 | Division of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455, Cerqueira César, São Paulo, SP 01246-903, Brazil. |
| 期刊 | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism |
| SCI 分区 | Q1 |
| IF | 6.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
Vemuganti及其同事强调了间歇性禁食（IF）通过自噬和线粒体生物发生在卒中后的神经保护潜力。然而，临床转化在代谢脆弱患者中面临障碍。本信批评了IF在床旁应用的可行性，强调卒中后分解代谢应激、吞咽困难（约50%病例）、肌少症风险和心血管问题。近期证据将短进食窗口与更高死亡率联系起来，与IF的益处相悖。肥胖悖论提示营养储备有助于生存。策略：优先蛋白质的规划、吞咽困难筛查、营养师监测和补充剂。在随机对照试验确认安全性/有效性之前，应优先考虑营养充足性。临床前见解值得研究。关键词：吞咽困难、间歇性禁食、神经保护、肥胖悖论、肌少症。
英文摘要
Vemuganti and colleagues highlight intermittent fasting (IF)'s neuroprotective potential post-stroke via autophagy and mitochondrial biogenesis. However, clinical translation faces hurdles in metabolically vulnerable patients. This letter critiques IF's bedside applicability, emphasizing post-stroke catabolic stress, dysphagia (~50% cases), sarcopenia risk, and cardiovascular concerns. Recent evidence links short eating windows to higher mortality, countering IF benefits. The obesity paradox suggests nutritional reserves aid survival. Strategies: protein-prioritized planning, dysphagia screening, dietitian monitoring, and supplements. Until RCTs confirm safety/efficacy, prioritize nutritional adequacy. Preclinical insights warrant study.Keywords: dysphagia, intermittent fasting, neuroprotection, obesity paradox, sarcopenia.