Article record

阻塞性睡眠呼吸暂停中呼出二氧化碳、氧气和一氧化二氮的夜间变化：与疾病严重程度及多导睡眠图表现的关联

Overnight changes in exhaled carbon dioxide, oxygen, and nitrous oxide in obstructive sleep apnea: associations with disease severity and polysomnographic findings.

临床研究鼻科IF 3.4Q2

文献信息

PMID	42899628
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Mustafa Buğra Buğra Coşkuner 查看其他 4 位作者 Buğra Kerget；Esra Sönmez；Huseyin Erdal；İsmail Bayraklı
作者单位	Aksaray Universitesi, Aksaray University Pulmonolgy Department, Aksaray, Aksaray, 68100, Turkey. 查看其他 4 条单位信息 Aksaray Universitesi, Department of Pulmonary Diseases, Aksaray University School of Medicine, 68200, Aksaray, Turkey, Aksaray, Aksaray, 68100, Turkey.；Aksaray Universitesi, Aksaray University Pulmonology Department, Aksaray, Aksaray, 68100, Turkey.；Aksaray Universitesi, Department of Medical Genetics, Faculty of Medicine, Aksaray University, Aksaray, Turkey, Aksaray, Aksaray, 68100, Turkey.；Electrical and Electronics Engineering, Aksaray Universitesi, Aksaray Electrical and Electronics Engineering, Aksaray, 68100, Turkey.
期刊	Journal of breath research
SCI 分区	Q2
IF	3.4
研究类型	临床研究 · 临床
所属专科	鼻科

中文摘要

呼出气体分析是一种用于评估阻塞性睡眠呼吸暂停（OSA）生理改变的无创方法。本研究评估了呼出CO₂、O₂和N₂O浓度的夜间变化及其与OSA严重程度和多导睡眠图参数的关联。
方法： 在这项前瞻性观察研究中，纳入62名接受诊断性夜间多导睡眠监测的成人，并根据呼吸暂停低通气指数分为无OSA组（n = 21）、轻至中度OSA组（n = 21）和重度OSA组（n = 20）。在标准化条件下，于夜间多导睡眠监测前和监测后立即测量呼出CO₂、O₂和N₂O浓度。
结果： 重度OSA患者晨间呼出N₂O浓度显著高于其他组（p = 0.001）。呼出CO₂（ΔCO₂）、N₂O（ΔN₂O）和O₂（ΔO₂）的夜间变化按OSA严重程度存在显著差异（均p < 0.001）。与无OSA组相比，OSA患者呼出CO₂和N₂O浓度的夜间升高幅度更大，同时呼出O₂浓度的下降幅度也更大。夜间ΔN₂O和ΔO₂与AHI呈强相关（分别为ρ = -0.760和0.912；均p < 0.001），与ODI也呈强相关（分别为ρ = -0.713和0.913；均p < 0.001）。
结论： OSA患者呼出气体组成的夜间变化更为明显，尤其是呼出O₂和N₂O浓度的变化更大。这些发现提示，夜间呼出气体的动态变化可能反映与OSA严重程度相关的生理改变，值得在更大规模的前瞻性研究中进一步验证。

英文摘要

Exhaled breath analysis is a non-invasive approach for assessing physiological alterations in obstructive sleep apnea (OSA). This study evaluated overnight changes in exhaled CO₂, O₂, and N₂O concentrations and their associations with OSA severity and polysomnographic parameters.Methods: In this prospective observational study, 62 adults undergoing diagnostic overnight polysomnography were enrolled and classified as having no OSA (n = 21), mild-to-moderate OSA (n = 21), or severe OSA (n = 20) according to the apnea-hypopnea index. Exhaled CO₂, O₂, and N₂O concentrations were measured immediately before and after overnight polysomnography under standardized conditions.Results: Morning exhaled N₂O concentrations were significantly higher in patients with severe OSA than in the other groups (p = 0.001). Overnight changes in exhaled CO₂ (ΔCO₂), N₂O (ΔN₂O), and O₂ (ΔO₂) differed significantly according to OSA severity (all p < 0.001). Compared with the no OSA group, patients with OSA exhibited greater overnight increases in exhaled CO₂ and N₂O concentrations together with greater decreases in exhaled O₂ concentrations. Overnight ΔN₂O and ΔO₂ showed strong correlations with AHI (ρ = -0.760 and 0.912, respectively; both p < 0.001) and ODI (ρ = -0.713 and 0.913, respectively; both p < 0.001).Conclusion: Patients with OSA exhibited more pronounced overnight alterations in exhaled gas composition, particularly greater changes in exhaled O₂ and N₂O concentrations. These findings suggest that dynamic overnight exhaled gas changes may reflect physiological alterations associated with OSA severity and warrant further validation in larger prospective studies.&#xD.