患者对嗅觉植入物可接受性观点的横断面研究

文献信息

中文摘要

目的： 与其他慢性疾病不同，嗅觉和味觉障碍（SATDs）的有效疗法仍然匮乏。嗅觉植入物是一个新兴的治疗领域，旨在通过电刺激嗅觉通路来恢复嗅觉。本调查旨在评估患者对嗅觉植入物的意见和可接受性，包括接受手术的意愿，以及影响其决策过程的因素。
设计与设置： 这是一项横断面调查，由两个在线问卷组成，通过慈善机构SmellTaste传播，探讨SATDs的特征和影响，以及在正式诊断或自我认同为SATDs的人群中对嗅觉植入物的意见。
结果： 共有410名参与者完成了评估一般人口统计学和嗅觉体验的主要问卷。另有47名参与者完成了第二份更深入的问卷，关于对嗅觉植入物的看法。在两份问卷中，女性受访者多于男性——这一趋势在SATDs研究中一直存在。绝大多数参与者愿意佩戴非植入式设备来帮助检测气味的数量和质量，特别是如果用于检测气体和火灾等危险。对手术植入设备的意见则更为多样。大多数患者在提及任何风险之前是愿意接受的，但进一步探究显示，了解任何程序的风险和成功率是指导患者决策的关键。
结论： 有嗅觉丧失的患者愿意使用嗅觉植入物；因此，需要对嗅觉植入物的安全性、可行性和有效性进行更广泛的研究。

英文摘要

OBJECTIVES: Unlike other chronic conditions, effective therapies for smell and taste disorders (SATDs) remain scarce. Olfactory implants are an emerging area of therapy aimed at restoring the sense of smell through electrical stimulation of the olfactory pathway. This survey aimed to assess patient opinions and the acceptability of olfactory implants, including willingness to undergo surgery, as well as factors influencing their decision-making process.
DESIGN AND SETTING: This was a cross-sectional survey consisting of two online questionnaires circulated via the charity SmellTaste, exploring features and impacts of SATDs, and opinions surrounding olfactory implants in those formally diagnosed or self-identifying with SATDs.
RESULTS: A total of 410 participants completed the primary questionnaire assessing general demographics and olfactory experiences. A further 47 participants completed the second, more in-depth questionnaire about the perceptions on olfactory implants. Across both questionnaires, more females responded than males-a trend seen throughout research on SATDs. An overwhelming majority of participants would be willing to wear a non-implantable device to help detect odour quantity and quality, especially if used to detect dangers such as gas and fires. Opinions on surgically implantable devices varied more. Most patients were amenable prior to any mention of risks, but further probing revealed understanding risks and success rates of any procedure were key to guiding patient decisions.
CONCLUSION: There are patients with olfactory loss who are willing to use an olfactory implant; therefore, more extensive research into the safety, viability and efficacy of olfactory implants is needed.