同步性喉鳞状细胞癌与膀胱乳头状尿路上皮癌：一例病例报告及文献综述

文献信息

中文摘要

背景： 同步性原发恶性肿瘤被定义为在六个月内于不同解剖部位发生的两种组织学上不同的肿瘤。尽管烟草暴露是公认的共同致癌因素，但喉鳞状细胞癌与膀胱尿路上皮癌共存仍属罕见。方法：我们报告一例75岁男性，有40包年吸烟史，表现为进行性发声困难。影像学显示局部晚期喉部肿瘤及偶然发现的膀胱病变。结果：组织病理学检查证实为高分化喉鳞状细胞癌及低级别非肌层浸润性膀胱乳头状尿路上皮癌，符合Warren和Gates同步性原发肿瘤标准。患者接受诱导化疗以保留喉功能，并接受经尿道膀胱肿瘤切除术及后续监测。结论：本病例强调在高危患者中进行系统筛查和多学科管理的重要性。

英文摘要

Synchronous primary malignancies are defined as two histologically distinct tumors arising in different anatomical sites within six months. Although tobacco exposure is a recognized shared carcinogenic factor, the coexistence of laryngeal squamous cell carcinoma and bladder urothelial carcinoma remains rare. We report the case of a 75-year-old man with a 40 pack-year smoking history who presented with progressive dysphonia. Imaging revealed a locally advanced laryngeal tumor and an incidental bladder lesion. Histopathological examination confirmed a well-differentiated laryngeal squamous cell carcinoma and a low-grade non-muscle-invasive papillary urothelial carcinoma of the bladder, fulfilling the Warren and Gates criteria for synchronous primary tumors. The patient underwent induction chemotherapy for laryngeal preservation and transurethral resection of the bladder tumor followed by surveillance. This case highlights the importance of systematic screening and multidisciplinary management in high-risk patients.