体重指数转变与过敏性鼻炎代谢性炎症的时间关联：一项回顾性队列研究
Temporal associations of BMI transition with metabolic inflammation in allergic rhinitis: A retrospective cohort study.
文献信息
| PMID | 42892857 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Siying Pan |
| 作者单位 | Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, 523808, China. |
| 期刊 | The World Allergy Organization journal |
| SCI 分区 | Q2 |
| IF | 4.8 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 在过敏性鼻炎（AR）患者中，体重指数（BMI）从正常转变为超重/肥胖与代谢性炎症之间的动态纵向关联仍不清楚。
方法： 我们开展了一项回顾性纵向队列研究，纳入2014年至2025年间在中国广东湛江广东医科大学附属医院就诊的1715例基线BMI正常的AR患者。采用靶向最大似然估计结合时间窗分析，估计BMI升高对1-3年内炎症和代谢标志物的平均治疗效应，并量化代谢性疾病的风险。
结果： BMI转变与全身炎症逐渐加重及持续性代谢紊乱相关。炎症标志物呈时间依赖性升高，而以甘油三酯升高和高密度脂蛋白胆固醇降低为特征的代谢异常出现更早且保持稳定。BMI增加还与多种代谢性疾病风险升高相关，尤其是脂肪肝疾病。
结论： 在AR患者中，从正常BMI转变为超重或肥胖与全身炎症逐渐增加及持续性代谢功能障碍相关，而后者与多种代谢性疾病风险升高相关。在对AR患者实施体重管理时，建议随时间监测体重变化，并在体重增加过程中早期干预。
英文摘要
BACKGROUND: In patients with allergic rhinitis (AR), the dynamic longitudinal association between transition from normal body mass index (BMI) to overweight/obesity and metabolic inflammation remains unclear.
METHODS: We conducted a retrospective longitudinal cohort study involving 1715 AR patients with normal baseline BMI between 2014 and 2025 at the Affiliated Hospital of Guangdong Medical University in Zhanjiang, Guangdong, China. Using targeted maximum likelihood estimation with time-window analysis, we estimated the average treatment effects of BMI increase on inflammatory and metabolic markers over 1-3 years and quantified risks of metabolic diseases.
RESULTS: BMI transition was associated with progressively increased systemic inflammation and persistent metabolic dysregulation. Inflammatory markers showed a time-dependent increase, whereas metabolic abnormalities, characterized by elevated triglycerides and reduced high-density lipoprotein cholesterol, appeared earlier and remained stable. BMI gain was also associated with increased risks of several metabolic diseases, particularly fatty liver disease.
CONCLUSION: In AR patients, transitioning from normal BMI to overweight or obesity was associated with a gradual increase in systemic inflammation and persistent metabolic dysfunction that was associated with increased risks of various metabolic diseases. When implementing weight management for patients with AR, it is recommended to monitor changes in body weight over time and intervene early in the weight gain process.