全球营养不良领导倡议标准定义的营养不良对口腔鳞状细胞癌预后的影响
Impact of malnutrition defined by Global Leadership Initiative on Malnutrition criteria on prognosis in oral squamous cell carcinoma.
文献信息
| PMID | 42888122 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Y Aiso |
| 作者单位 | Department of Oral Oncology, Oral and Maxillofacial Surgery, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan; Oral Cancer Center, Tokyo Dental College, Chiba, Japan. |
| 期刊 | International journal of oral and maxillofacial surgery |
| SCI 分区 | Q2 |
| IF | 2.7 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 口腔鳞状细胞癌（OSCC）患者可能因疼痛、吞咽困难等口腔功能障碍而在治疗前出现营养不良。然而，采用全球营养不良领导倡议（GLIM）标准评估OSCC患者术前营养不良及其预后影响的数据有限。目的：本研究旨在探讨采用GLIM标准评估的术前营养不良与OSCC患者总生存期和无病生存期之间的关联。方法：本回顾性研究纳入187例接受初次手术治疗的原发性OSCC患者。采用GLIM标准评估术前营养状况，并分为非营养不良、中度营养不良或重度营养不良。采用Cox比例风险模型分析总生存期和无病生存期。结果：在本研究纳入的187例患者中，按GLIM标准诊断营养不良者占18.2%，其中中度营养不良11.2%，重度营养不良7.0%。在多变量Cox比例风险分析中，GLIM标准定义的重度营养不良被确定为总生存期（风险比（HR）3.09，95%置信区间（CI）1.52-6.31，P < 0.01）和无病生存期（HR 2.27，95% CI 1.19-4.32，P = 0.02）的独立不良预后因素。结论：采用GLIM标准评估的术前营养不良，尤其是重度营养不良，对OSCC患者的预后具有显著影响。需要进一步研究评估旨在改善营养不良OSCC患者生存结局的营养干预和支持治疗。
英文摘要
Patients with oral squamous cell carcinoma (OSCC) may present with malnutrition prior to treatment due to oral dysfunction such as pain and dysphagia. However, limited data are available regarding the preoperative malnutrition and its prognostic impact in OSCC patients when assessed using the Global Leadership Initiative on Malnutrition (GLIM) criteria. The purpose of this study was to investigate the association between preoperative malnutrition assessed by the GLIM criteria and overall survival and disease-free survival in patients with OSCC. This retrospective study included 187 patients with OSCC who underwent primary surgical treatment. Preoperative nutritional status was evaluated using the GLIM criteria and classified as non-malnutrition, moderate malnutrition, or severe malnutrition. Overall survival and disease-free survival were analyzed using Cox proportional hazards models. Among the 187 patients included in this study, malnutrition according to the GLIM criteria was diagnosed in 18.2% of the patients, including 11.2% with moderate malnutrition and 7.0% with severe malnutrition. In multivariable Cox proportional hazards analysis, severe malnutrition defined by the GLIM criteria was identified as an independent unfavorable prognostic factor for both overall survival (hazard ratio (HR) 3.09, 95% confidence interval (CI) 1.52-6.31, P < 0.01) and disease-free survival (HR 2.27, 95% CI 1.19-4.32, P = 0.02). Preoperative malnutrition assessed by the GLIM criteria, particularly severe malnutrition, was shown to have a significant impact on prognosis in patients with OSCC. Further studies are required to evaluate nutritional interventions and supportive care aimed at improving survival outcomes in malnourished OSCC patients.