用于可植入驱动的可膨胀水凝胶-硅胶双层的资格验证。

文献信息

中文摘要

为了提高人工耳蜗电极载体的结构适应性和生物适用性，本研究系统开发并评估了新型3D打印可膨胀水凝胶-硅胶复合材料。将乙烯基膦酸-丙烯酰胺水凝胶粉末（VPA-AAm）预洗、研磨和过筛，掺入硅胶基质中，并在快速热固化前进行3D打印，随后进行微观结构、膨胀和体外WST-1细胞毒性分析。预洗减少了颗粒团聚并促进了高分辨率打印。掺入水凝胶在25 wt.%时导致完全宏观不透明，并在快速热固化过程中产生局部微孔。非渗流形态影响了复合材料的膨胀和质量传输，为水吸收与观察到的细胞活力反应之间提供了机制联系。虽然35 wt.%的负载与基质降解和细胞活力低于70%阈值相关，但30 wt.%组合物实现了约400-460%的最高吸水率，这与渗透膨胀和基质弹性之间的有利平衡一致。这种膨胀行为与中间水凝胶负载下的受控释放特性和非细胞毒性提取物反应相关。因此，30 wt.%复合材料代表了一种有前景的可植入医疗器械材料组合，在所研究的提取条件下平衡了膨胀性能、结构稳定性和良好的体外细胞活力。

英文摘要

To improve the structural adaptability and biological suitability of cochlear implant electrode carriers, this study systematically develops and evaluates novel 3D-printed, swellable hydrogel-silicone composites. A vinylphosphonic acid-acrylamide hydrogel powder (VPA-AAm) was pre-washed, milled, and sieved, incorporated into a silicone matrix, and 3D-printed before rapid thermal curing, followed by microstructural, swelling, and in vitro WST-1 cytotoxicity analyses. Pre-washing minimized particle agglomeration and facilitated high-resolution printing. Incorporating the hydrogel induced complete macroscopic opacity at 25 wt.% and localized microporosity during rapid thermal curing. The non-percolating morphology influenced swelling and mass transport through the composite, providing a mechanistic link between water uptake and the observed cell-viability response. While a 35 wt.% loading was associated with matrix degradation and cell viability below the 70% threshold, the 30 wt.% composition achieved the highest water absorption of approximately 400-460%, consistent with a favorable balance between osmotic swelling and matrix elasticity. This swelling behavior was associated with controlled release characteristics and non-cytotoxic extract responses at intermediate hydrogel loading. Consequently, the 30 wt.% composite represents a promising material combination for implantable medical devices, balancing swelling performance, structural stability, and favorable in vitro cell viability under the investigated extraction conditions.