慢性鼻窦炎与下气道黏液栓形成相关
Chronic Rhinosinusitis Is Associated with Lower Airway Mucus Plugging.
文献信息
| PMID | 42882070 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Akane Masuda |
| 作者单位 | Department of Respiratory Medicine, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. |
| 期刊 | Journal of clinical medicine |
| SCI 分区 | Q1 |
| IF | 3.5 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 慢性鼻窦炎（CRS）与下气道疾病相关，但其与黏液栓形成的关系仍不明确。我们研究了CRS与下气道黏液栓形成之间的关联。
方法： 这项单中心回顾性观察研究纳入了接受鼻窦计算机断层扫描和胸部高分辨率计算机断层扫描的患者。评估了CRS与黏液栓形成之间的关联，包括根据嗜酸性慢性鼻窦炎（ECRS）状态进行的分型分析。
结果： 在97例患者中，51例患有CRS，46例未患CRS。CRS患者的黏液栓形成比无CRS者更常见（41.2% vs. 10.9%，p = 0.001），且CRS组的黏液栓评分更高（p = 0.002）。在调整哮喘和支气管扩张后，CRS仍与黏液栓形成独立相关（调整比值比，4.06；95%置信区间，1.30-12.7；p = 0.016）。非ECRS组和ECRS组的黏液栓形成均比非CRS组更常见，两种CRS表型之间无显著差异。
结论： 在调整哮喘和支气管扩张后，CRS仍与黏液栓形成相关。黏液栓形成可能是CRS中下气道一个未被充分认识的影像学特征。
英文摘要
Background: Chronic rhinosinusitis (CRS) is associated with lower airway diseases, but its relationship with mucus plugging remains unclear. We investigated the association between CRS and lower airway mucus plugging. Methods: This single-center retrospective observational study included patients who underwent paranasal sinus computed tomography and chest high-resolution computed tomography. Associations between CRS and mucus plugging were evaluated, including phenotype-stratified analyses according to eosinophilic CRS (ECRS) status. Results: Among 97 patients, 51 had CRS and 46 did not. Mucus plugging was more frequent in patients with CRS than in those without CRS (41.2% vs. 10.9%, p = 0.001), and mucus plug scores were higher in the CRS group (p = 0.002). CRS remained independently associated with mucus plugging after adjustment for asthma and bronchiectasis (adjusted odds ratio, 4.06; 95% confidence interval, 1.30-12.7; p = 0.016). Mucus plugging was more prevalent in both the non-ECRS and ECRS groups than in the non-CRS group, with no significant difference between the two CRS phenotypes. Conclusions: CRS remained associated with mucus plugging after adjustment for asthma and bronchiectasis. Mucus plugging may represent an underrecognized radiological feature of the lower airways in CRS.