细颗粒物（PM2.5）与粗颗粒物（PM10-2.5）对鼻咽癌患者生存结局的影响：泰国北部一家三级医疗中心的回顾性队列研究
The Effect of Fine (PM2.5) and Coarse (PM10-2.5) Particulate Matter on Survival Outcomes in Nasopharyngeal Carcinoma Patients: A Retrospective Cohort Study in a Northern Thailand Tertiary Care Center.
文献信息
| PMID | 42881829 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Weerachai Watcharatsiriyuth |
| 作者单位 | Department of Otolaryngology, Chiang Mai University, Chiang Mai 50200, Thailand. |
| 期刊 | Journal of clinical medicine |
| SCI 分区 | Q1 |
| IF | 3.5 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻咽癌 |
中文摘要
目的： 本研究旨在探讨环境细颗粒物（PM2.5）和粗颗粒物（PM10-2.5）暴露与鼻咽癌患者生存结局之间的关联。
方法： 对鼻咽癌患者进行了一项回顾性研究。环境颗粒物和气态空气污染物的年均水平取自泰国污染控制厅。采用Cox比例风险模型评估PM2.5和PM10-2.5暴露（按浓度四分位数分为四组）与生存结局之间的关联。
结果： 共纳入140例患者。5年总生存期（OS）和无病生存期（DFS）分别为73.1%和61.9%。单因素和多因素分析显示，PM2.5暴露增加与OS或DFS无显著关联。在多因素分析中，较高的PM10-2.5暴露类别与较差的生存结局相关。与最低暴露四分位组患者相比，最高PM10-2.5暴露四分位组患者在比较浓度第4四分位与第1四分位时，OS（aHR 8.12，95% CI 1.30-15.27）和DFS（aHR 9.17，95% CI 4.58-13.98）均显著更差。
结论： 高PM10-2.5暴露与鼻咽癌患者死亡和疾病复发风险增加相关，在最高与最低暴露四分位之间观察到具有统计学意义的关联。
英文摘要
Objective: This study aimed to examine the association between exposure to ambient fine (PM2.5) and coarse (PM10-2.5) particulate matter and survival outcomes among patients with nasopharyngeal carcinoma. Methods: A retrospective study was conducted among patients with nasopharyngeal carcinoma. Annual mean levels of ambient particulate matter and gaseous air pollutants were assessed from the Thailand Pollution Control Department. The Cox proportional hazards model was used to estimate the association between exposure to PM2.5 and PM10-2.5, categorized into four concentration quartiles, and survival outcomes. Results: One hundred and forty patients were included. Five-year overall survival (OS) and disease-free survival (DFS) were 73.1% and 61.9%, respectively. Univariable and multivariable analyses showed that increased PM2.5 exposure was not significantly associated with OS or DFS. In multivariable analysis, higher PM10-2.5 exposure categories were associated with poorer survival outcomes. Compared with patients in the lowest exposure quartile, those in the highest PM10-2.5 exposure quartile demonstrated significantly poorer OS (aHR 8.12, 95% CI 1.30-15.27) and DFS (aHR 9.17, 95% CI 4.58-13.98) when comparing the 4th with the 1st quartiles of concentration. Conclusions: High exposure to PM10-2.5 was associated with an increased risk of death and disease recurrence in patients with nasopharyngeal carcinoma, with statistically significant associations observed between the highest and lowest exposure quartiles.