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舌下过敏原免疫治疗（OSIRIS）后出现行为性抽动：一例病例报告
Behavioral tics following sublingual allergen immunotherapy (OSIRIS): A case report.
文献信息
| PMID | 42881067 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Ludivine Traverso |
| 作者单位 | Service de pharmacologie médicale et clinique, centre de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament (CRPV), centre d'investigation clinique CIC 1436, CHU de Toulouse, 31000 Toulouse, France. Electronic address: traverso.l@chu-toulouse.fr. |
| 期刊 | Therapie |
| SCI 分区 | Q3 |
| IF | 2.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
我们报告一例14岁男孩，在接受OSIRIS Acariens混合制剂舌下免疫治疗过敏性鼻炎后出现运动性和发声性抽动。抽动在暂时停药后缓解，再次用药后重新出现。据我们所知，这是首例与该过敏原提取物相关的此类不良事件报告。我们讨论了过敏性疾病、免疫治疗与抽动障碍之间的潜在联系，强调需要仔细监测意外不良事件。
英文摘要
We report the case of a 14-year-old boy who developed motor and vocal tics following sublingual immunotherapy with OSIRIS Acariens mix for allergic rhinitis. The tics resolved upon temporary discontinuation and reappeared upon rechallenge. To our knowledge, this is the first report of such an adverse event associated with this allergen extract. We discuss the potential link between allergic diseases, immunotherapy, and tic disorders, highlighting the need for careful monitoring of unexpected adverse events.