Article record

健康生活方式作为胃食管反流病风险的保护因素：前瞻性人群队列分析

Healthy lifestyle as a protective factor against the risk of gastroesophageal reflux disease: Prospective population cohort analysis.

临床研究咽喉科IF 3.3Q2

文献信息

PMID	42879421
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Lei Peng 查看其他 12 位作者 Xueqin Li；Jinfeng Qi；Liming Zhang；Zhenqing Yang；Xucheng Wu；Xueqing Jia；George O Agogo；Guoju Liu；Kongxi Zhu；Zuyun Liu；Genxiang Mao；Honglei Wu
作者单位	Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. 查看其他 4 条单位信息 Center for Clinical Big Data and Analytics of the Second Affiliated Hospital, and Department of Big Data in Health Science School of Public Health, the Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.；Division of Global Health Protection, U.S. Centers for Disease Control and Prevention (CDC), Nairobi, Kenya.；Department of Physiology, Shandong Medical College, Jinan, Shandong, China.；Zhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou, China.
期刊	PloS one
SCI 分区	Q2
IF	3.3
研究类型	临床研究 · 临床
所属专科	咽喉科

中文摘要

背景： 美国胃肠病学会（AGA）推荐通过生活方式调整来管理胃食管反流病（GERD）这一重要健康问题；但相关证据稀缺。本研究旨在探讨健康生活方式行为与GERD风险之间的纵向关联。
方法： 我们分析了英国生物银行（UK Biobank）中306,543名基线时无GERD、年龄在38至73岁之间的参与者的数据。使用七个项目计算了汇总的健康生活方式评分（范围0-7分）：从不吸烟、健康睡眠、适度体重指数（BMI）、规律体育锻炼、适度饮酒、健康饮食以及适度茶/咖啡摄入。采用多变量Cox回归分析来检验这些关联。
结果： 在平均12.7年的随访期间，共识别出27,943例（9.1%）GERD病例。除适度饮酒（风险比[HR]，1.00；95%置信区间[CI]：0.98-1.03）外，每一种健康生活方式均与较低的GERD风险相关。与汇总健康生活方式评分低于2分的参与者相比，评分为2、3、4和5-7分的参与者GERD风险显著降低，HR分别为0.94（95% CI：0.90-0.98）、0.83（0.80-0.86）、0.74（0.71-0.77）、0.63（0.60-0.66）（趋势P<0.001）。分层分析显示，上述关联在较年轻（<60岁）、女性和在职的参与者中更为明显（交互作用P均<0.05）。敏感性分析显示了相似的结果。
结论： 本研究强调了坚持健康生活方式行为在降低一般人群中GERD患病率方面的重要性。

英文摘要

BACKGROUND: Lifestyle modifications are recommended by American Gastroenterological Association (AGA) for managing gastroesophageal reflux disease (GERD), a significant health issue; but evidence is scarce. This study aims to investigate the longitudinal association between healthy lifestyle behaviors and the risk of GERD.
METHODS: We analyzed data from 306,543 participants aged between 38 and 73 years without GERD at baseline from the UK Biobank. A summarized healthy lifestyle score (range, 0-7) was calculated using seven items: never smoking, healthy sleep, moderate body mass index (BMI), regular physical exercise, moderate alcohol intake, healthy diet, and moderate tea/coffee intake. Multivariable Cox regression was performed to examine the associations.
RESULT: During a mean follow-up of 12.7 years, 27,943 (9.1%) GERD cases were identified. Each healthy lifestyle, except for moderate alcohol intake (hazard ratios [HR], 1.00; 95% confidence interval [CI]: 0.98-1.03) was associated with a lower risk of GERD. Relative to participants with less than 2 of summarized healthy lifestyle score, those with 2, 3, 4, and 5-7 of this score showed a significantly lower risk of GERD, with the HR of 0.94 (95% CI: 0.90-0.98), 0.83 (0.80-0.86), 0.74 (0.71-0.77), 0.63 (0.60-0.66), respectively (P for trend <0.001). Stratified analysis shows that the above associations were more pronounced among participants who were younger (< 60 years), female and employed (all P for interaction <0.05). Sensitivity analyses demonstrated similar results.
CONCLUSIONS: This study highlights the importance of adherence to healthy lifestyle behaviors in reducing the prevalence of GERD in the general population.