区分慢性鼻窦炎的内型：巨噬细胞的新兴作用
Distinguishing the endotypes of Chronic rhinosinusitis: the emerging roles of macrophages.
文献信息
| PMID | 42878110 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Zhibo Wang |
| 作者单位 | Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China. |
| 期刊 | Expert review of clinical immunology |
| SCI 分区 | Q2 |
| IF | 4.1 |
| 研究类型 | 综述 Meta · 基础／转化 |
| 所属专科 | 鼻科 |
中文摘要
引言： 慢性鼻窦炎（CRS）是一种异质性炎症性疾病，其特征为经典已知的1型/2型/3型炎症等不同内型。巨噬细胞在CRS的发病机制中发挥关键作用。在不同的炎症条件下，巨噬细胞可极化为不同亚群，并在CRS各内型中发挥不同功能。近年来，单细胞转录组分析鉴定出一系列具有与CRS内型相关的特定基因表达特征的巨噬细胞亚群。
涵盖领域： 使用PubMed进行文献检索，关键词为“CRS”、“内型”和“巨噬细胞”及相关术语，聚焦于过去10年发表的研究。本综述剖析了CRS内型中巨噬细胞的异质性，总结了多种刺激因素如何塑造巨噬细胞状态，并更新了它们在内型中的作用，为开发基于巨噬细胞的生物标志物用于内型分型和靶向治疗提供线索。
专家意见： 有效区分CRS内型对个性化治疗具有重要意义。基于内型解读巨噬细胞异质性有助于解释CRS中炎症的不同模式。此外，鼻组织驻留巨噬细胞因其在CRS嗅觉丧失中的作用而日益受到关注。
英文摘要
INTRODUCTION: Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder characterized by different endotypes classically known as type 1/2/3 inflammation. Macrophages play a pivotal role in the pathogenesis of CRS. Under diverse inflammatory conditions, macrophages can polarize into different subsets and exert distinct functions across CRS endotypes. Recently, single-cell transcriptome analysis identified a series of macrophage subsets that have specific gene expression signatures associated with CRS endotypes.
AREAS COVERED: A literature search was conducted using PubMed with keywords 'CRS,' 'endotype,' and 'macrophage' and related terms, focusing on studies published over the past 10 years. This review dissects macrophage heterogeneity across CRS endotypes, summarizes how diverse stimulus factors shape macrophage states, and updates their roles under endotypes, providing clues for the development of macrophage-based biomarkers for endotyping and targeted therapy.
EXPERT OPINION: Effectively distinguishing CRS endotypes is meaningful for personalized therapies. An endotype-based interpretation of macrophage heterogeneity helps explain the divergent patterns of inflammation in CRS. In addition, the nasal tissue-resident macrophages attract growing interest as their contribution to olfactory loss in CRS.