单侧梅尼埃病中的眼性前庭诱发肌源性电位：一项叙述性文献综述。

文献信息

中文摘要

眼性前庭诱发肌源性电位（oVEMP）是一种有前景的非侵入性工具，用于评估椭圆囊功能和前庭上神经完整性。在明确单侧梅尼埃病的背景下，研究一致报道患侧耳的oVEMP反应发生改变，包括波幅改变、在获得可验证反应前需要更高的刺激强度或潜伏期延长。这些发现被认为反映了内淋巴积水的存在和积聚。然而，研究之间的变异性很大。这种不一致可能反映了梅尼埃病症状特征性的内淋巴压力或容量的波动性变化以及由此导致的耳石功能变异性，以及疾病分期和进展、刺激参数和记录方法的差异。oVEMP发现对梅尼埃病的特异性仍受到刺激方式（气导与骨导）、刺激强度、刺激设置（例如上升和下降时间及持续时间）以及记录方案变异的限制。由于oVEMP主要评估椭圆囊功能，它提供的信息可补充其他前庭终器或神经通路的常规前庭测试，如冷热试验、视频头脉冲试验和颈性VEMP。虽然oVEMP可能有助于梅尼埃病的多模式评估，但在其诊断价值能够在临床和实验研究之间可靠比较之前，还需要进一步标准化。还需要纵向研究来确定oVEMP反应如何随疾病分期、疾病进展以及治疗后而变化。

英文摘要

The ocular vestibular-evoked myogenic potential (oVEMP) is a promising non-invasive tool for assessing utricular function and superior vestibular nerve integrity. In the context of definite unilateral Ménière's disease, studies have consistently reported altered oVEMP responses in affected ears, including altered amplitudes, higher stimuli needed before receiving a verifiable response or prolonged latencies. These findings are thought to reflect the presence and accumulation of endolymphatic hydrops. However, variability across studies is substantial. This inconsistency may reflect fluctuating changes in endolymphatic pressure or volume and consequent variability in otolith function that characterise Ménière's disease symptoms, as well as differences in disease stage and progression, stimulus parameters and recording methodologies. The specificity of oVEMP findings for Ménière's disease remains limited by variation in stimulus modality (air- versus bone-conducted), stimulus intensity, stimulus settings (e.g., rise and fall time, and duration) and recording protocol. Because oVEMP primarily assesses utricular function, it provides information that complements conventional vestibular tests of other vestibular end organs or neural pathways such as caloric testing, video head impulse testing and cervical VEMP. While oVEMP may contribute to a multimodal assessment of Ménière's disease, further standardisation is required before its diagnostic value can be reliably compared across clinical and experimental studies. Longitudinal studies are also needed to establish how oVEMP responses change with disease stage, disease progression, and following treatment.