月经周期阶段和血清雌激素水平对女性鼓室成形术结局的影响。
Influence of menstrual cycle phase and serum oestrogen levels on tympanoplasty outcomes in women.
文献信息
| PMID | 42876238 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Nurcan Yoruk |
| 作者单位 | Department of Obstetrics and Gynecology, Erzurum Training and Research Hospital, Türkiye. |
| 期刊 | The Journal of laryngology and otology |
| SCI 分区 | Q3 |
| IF | 1.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 评估月经周期阶段和血清雌激素是否影响绝经前女性鼓室成形术的结局。
方法： 80例小型中央性鼓膜穿孔女性（卵泡期，第1-5天，n = 40；排卵期，第12-16天，n = 40）接受了内镜下经耳道I型鼓室成形术。结局为解剖学成功（12周时）和听力改善。评估了术前血清雌激素及其预测价值。
结果： 排卵期的移植成功率高于卵泡期（90% vs 70%，p = 0.025）。排卵期的听力增益更大（12.35 ± 4.84 dB vs 4.70 ± 3.92 dB，p < 0.001）。排卵期血清雌激素显著更高。受试者工作特征分析显示预测性能中等（曲线下面积 = 0.643）。
结论： 排卵期进行鼓室成形术与更好的解剖学和功能结局相关，提示内源性雌激素有益于鼓膜愈合。
英文摘要
OBJECTIVE: To evaluate whether menstrual cycle phase and serum oestrogen influence tympanoplasty outcomes in premenopausal women.
METHODS: Eighty women with small central tympanic membrane perforations (follicular phase, days 1-5, n = 40; ovulatory phase, days 12-16, n = 40) underwent endoscopic transcanal type I tympanoplasty. Outcomes were anatomical success (at 12 weeks) and hearing improvement. Pre-operative serum oestrogen and its predictive value were assessed.
RESULTS: Graft success was higher in the ovulatory than follicular phase (90 vs 70 per cent, p = 0.025). Hearing gain was greater in the ovulatory phase (12.35 ± 4.84 dB vs 4.70 ± 3.92 dB, p < 0.001). Serum oestrogen was significantly higher in the ovulatory phase. Receiver operating characteristic analysis showed modest predictive performance (area under the curve = 0.643).
CONCLUSION: Tympanoplasty during the ovulatory phase is associated with improved anatomical and functional outcomes, suggesting that endogenous oestrogen benefits tympanic membrane healing.