负压鼻腔冲洗治疗儿童慢性鼻窦炎的疗效与安全性：一项回顾性队列研究
Efficacy and safety of negative-pressure nasal irrigation in pediatric chronic rhinosinusitis: A retrospective cohort study.
文献信息
| PMID | 42874493 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Zhangming Li |
| 作者单位 | Department of Radiology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. |
| 期刊 | International journal of pediatric otorhinolaryngology |
| SCI 分区 | Q2 |
| IF | 1.7 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 儿童慢性鼻窦炎（CRS）影响6.37%的中国儿童。负压鼻腔冲洗（NNPI）被中国指南推荐，但国际证据仍然有限。
目的： 评估NNPI联合标准药物治疗儿童CRS的疗效与安全性。
方法： 对200名（3-6岁）CRS患儿进行回顾性队列研究。100名接受NNPI加标准治疗的儿童与100名仅接受标准治疗14天的儿童进行匹配。所有儿童在入组前一个月内均未接受过鼻内皮质类固醇和鼻腔冲洗治疗。主要结局为症状评分变化。
结果： 14天后，NNPI组在咳嗽（1.10 ± 0.30 vs. 1.96 ± 0.86；P < 0.001）、鼻塞（1.62 ± 1.19 vs. 1.97 ± 1.05；P = 0.028）和流涕（1.15 ± 0.46 vs. 1.97 ± 1.05；P < 0.001）方面显示出更大的减少。总有效率更高（90.0% vs. 75.0%；P = 0.005）。不良事件轻微（9.0% vs. 3.0%；P = 0.074）。未发生呼吸窘迫、误吸或操作不耐受的情况。
结论： NNPI联合标准治疗显著提高了儿童CRS的疗效，且安全性良好。然而，由于缺乏常规冲洗对照组且随访时间短，这些发现应谨慎解读，并需要在观察时间更长的前瞻性研究中验证。
英文摘要
BACKGROUND: Pediatric chronic rhinosinusitis (CRS) affects 6.37% of Chinese children. Negative-pressure nasal irrigation (NNPI) is recommended by Chinese guidelines, but international evidence remains limited.
OBJECTIVE: To evaluate efficacy and safety of NNPI combined with standard medical therapy in pediatric CRS.
METHODS: Retrospective cohort study of 200 children (3-6 years) with CRS. One hundred children receiving NNPI plus standard therapy were matched with 100 receiving standard therapy alone for 14 days. All children were treatment-naïve to intranasal corticosteroids and nasal irrigation within one month prior to enrollment. Primary outcomes were symptom score changes.
RESULTS: After 14 days, NNPI group showed greater reductions in cough (1.10 ± 0.30 vs. 1.96 ± 0.86; P < 0.001), nasal obstruction (1.62 ± 1.19 vs. 1.97 ± 1.05; P = 0.028), and rhinorrhea (1.15 ± 0.46 vs. 1.97 ± 1.05; P < 0.001). Total effective rate was higher (90.0% vs. 75.0%; P = 0.005). Adverse events were mild (9.0% vs. 3.0%; P = 0.074). No instances of respiratory distress, aspiration, or procedure intolerance occurred.
CONCLUSIONS: NNPI combined with standard therapy significantly improves efficacy in pediatric CRS with good safety. However, given the lack of a conventional irrigation control group and the short follow-up period, these findings should be interpreted cautiously and warrant validation in prospective studies with longer observation.