轻度地中海贫血儿童扁桃体切除术后血液学变化建议。
Haematological changes after tonsillectomy in mild thalassemia children recommendations.
文献信息
| PMID | 42874299 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Jianmin Huang |
| 作者单位 | Department of Otorhinolaryngology, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China. |
| 期刊 | Brazilian journal of otorhinolaryngology |
| SCI 分区 | Q2 |
| IF | 2.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
目的： 本研究旨在评估诊断为轻度地中海贫血的儿科患者行扁桃体切除术后外周血参数的变化及治疗结局。
方法： 我们开展了一项前瞻性队列研究，纳入2023年5月至2025年3月期间接受扁桃体切除术（伴或不伴腺样体切除术）的65名儿童。地中海贫血患者被分配至贫血组（n=30），而同期接受手术的无基础疾病者被纳入对照组（n=35）。比较两组在术后1天、7天、1个月、3个月和6个月时白细胞计数、中性粒细胞百分比、红细胞计数和血红蛋白水平的变化。同时比较术后恢复情况和并发症。
结果： 两组中，白细胞计数、中性粒细胞百分比、红细胞计数和血红蛋白水平在术后1天和7天均较术前水平显著升高（p<0.05）。贫血组术后红细胞计数和血红蛋白水平的变化分别在术后一周和一个月时显著大于对照组（p<0.05）。两组在术后打鼾缓解、出血、发热、咽痛或头晕的发生率方面无显著差异（p>0.05）。
结论： 扁桃体切除术被证明是缓解轻度地中海贫血儿童打鼾的安全有效干预措施。术后无需定期监测血液参数和常规输血。这一结论得到轻度地中海贫血队列中无显著术后血液学恶化或并发症风险增加的支持。
证据等级： 2b。
英文摘要
OBJECTIVE: This study aims to evaluate the alterations in peripheral blood parameters and the therapeutic outcomes following tonsillectomy in pediatric patients diagnosed with mild thalassemia.
METHODS: We conducted a prospective cohort study involving 65 children who underwent tonsillectomy (with or without adenoidectomy) between May 2023 to March 2025. Patients with thalassemia were assigned to the anaemia group (n = 30), while those without underlying diseases who underwent surgery during the same period were included in the control group (n = 35). The changes in white blood cell count, neutrophil percentage, red blood cell count and hemoglobin level were compared between the two groups at 1-day, 7-days, 1-month, 3-months, and 6-months postoperatively. Postoperative recovery and complications were also compared.
RESULTS: In both groups, white blood cell count, neutrophil percentage, red blood cell count and hemoglobin level showed significant increases at both 1-day and 7-days post-surgery compared to preoperative levels (p < 0.05). The postoperative changes in red blood cell count and hemoglobin level were significantly larger in the anaemia group than the control group at one week and one month after surgery, respectively (p < 0.05). There were no significant differences in the incidence of postoperative snoring relief, bleeding, fever, sore throat, or dizziness between the two groups (p > 0.05).
CONCLUSION: Tonsillectomy proves to be a safe and effective intervention for alleviating snoring in children with mild thalassemia. After the surgery, regular monitoring of blood parameters and routine transfusions are not required. This conclusion is supported by the absence of significant postoperative haematological deterioration or an increased risk of complications in the mild thalassemia cohort.
LEVEL OF EVIDENCE: 2b.