使用皮下免疫治疗提取物配制舌下免疫治疗滴剂的剂量计算：对尘螨和猫免疫治疗的意义。

文献信息

中文摘要

在美国，舌下免疫治疗滴剂（SLIT-D）通常使用为皮下免疫治疗（SCIT）生产的提取物。使用目标每日主要过敏原剂量以及提取物的主要过敏原浓度，可以计算维持性SLIT药瓶所需的提取物体积。尽管尚未确定最佳的统一SLIT-D剂量，但已发表的剂量建议为说明这些计算提供了实用基准。以8 mL药瓶中15 µg/天的说明性目标为例，含20 µg/mL Fel d 1的猫提取物需要24 mL，而含60 µg/mL Der p 1的尘螨提取物需要8 mL。本评论提出了一种基于已发表过敏原浓度数据的实用剂量估算框架，并强调了较低的主要过敏原浓度可能如何限制SLIT-D的配制。

英文摘要

Sublingual immunotherapy drops (SLIT-D) in the US commonly use extracts manufactured for subcutaneous immunotherapy (SCIT). Using a target daily major allergen dose together with the extract major allergen concentration allows calculation of the extract volume necessary for a maintenance SLIT vial. Although an optimal universal SLIT-D dose has not been established, published dosing recommendations provide practical benchmarks for illustrating these calculations. Using an illustrative target of 15 µg/day in an 8-mL vial, cat extract containing 20 µg/mL Fel d 1 would require 24 mL, whereas dust mite extract containing 60 µg/mL Der p 1 would require 8 mL. This Commentary presents a practical dose-estimation framework based on published allergen concentration data and highlights how lower major-allergen concentrations may constrain SLIT-D formulation.