剪切波弹性成像评估阻塞性睡眠呼吸暂停患者的上气道肌肉硬度
Upper Airway Muscle Stiffness in Obstructive Sleep Apnea Assessed by Shear Wave Elastography.
文献信息
| PMID | 42869780 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Buğra Kerget |
| 作者单位 | Department of Pulmonary Diseases, Aksaray University School of Medicine, Aksaray, Turkey. |
| 期刊 | Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine |
| SCI 分区 | Q2 |
| IF | 2.3 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
目的： 在阻塞性睡眠呼吸暂停（OSA）中，以反复发作的呼吸暂停和低通气为特征，上气道扩张肌的活动具有重要意义。在本研究中，我们旨在比较OSA患者颏舌肌（GG）、颏舌骨肌（GH）和下颌舌骨肌（MH）的剪切波弹性成像（SWE）值。
方法： 在这项前瞻性研究中，纳入了90名接受整夜多导睡眠监测的成年人。参与者被分类为非OSA（呼吸暂停低通气指数[AHI] <5，n=32）或OSA（AHI ≥5，n=58），OSA患者进一步按严重程度划分。使用SWE评估双侧GG、双侧MH和GH肌肉的硬度。
结果： OSA患者双侧GG和GH硬度值显著高于非OSA个体，而双侧MH测量值在组间无差异（P < .001、.006和.004）。在OSA亚组中，重度OSA的左侧GG硬度显著高于轻中度OSA（P = .043）。右侧GG硬度与AHI和仰卧位AHI呈正相关（r = 0.392和r = 0.491；均P < .001）。左侧GG硬度与AHI和快速眼动期AHI呈正相关（r = 0.338，P = .001；r = 0.423，P < .001）。GH硬度与AHI和氧减饱和度指数均呈正相关（r = 0.313，P = .003；r = 0.302，P = .004）。
结论： SWE可能为评估OSA患者上气道肌肉特征提供一种有用的无创工具。观察到上气道肌肉硬度与多导睡眠监测参数之间的关联；然而，这些横断面发现应被视为探索性和假设生成性的，需要在更大规模的研究中确认。
英文摘要
OBJECTIVE: In obstructive sleep apnea (OSA), characterized by recurrent episodes of apnea and hypopnea, the activity of the upper airway dilator muscles is significant. In our study, we aimed to compare shear wave elastography (SWE) values of the genioglossus (GG), geniohyoid (GH), and mylohyoid (MH) muscles in patients with OSA.
METHODS: In this prospective study, 90 adults who underwent full-night polysomnography were included. Participants were classified as non-OSA (apnea-hypopnea index [AHI] <5, n = 32) or OSA (AHI ≥5, n = 58), and OSA patients were further divided by severity. SWE was used to assess the stiffness of the bilateral GG, bilateral MH, and GH muscles.
RESULTS: Bilateral GG and GH stiffness values were significantly higher in OSA patients than in non-OSA individuals, whereas bilateral MH measurements did not differ between groups (P < .001, .006, and .004, respectively). Among OSA subgroups, left GG stiffness was significantly higher in severe OSA than in mild-moderate OSA (P = .043). Right GG stiffness showed positive correlations with AHI and supine AHI (r = 0.392 and r = 0.491, respectively; both P < .001). Left GG stiffness was positively correlated with AHI and rapid eye movement-AHI (r = 0.338, P = .001; r = 0.423, P < .001). GH stiffness was positively correlated with both AHI and oxygen desaturation index (r = 0.313, P = .003; r = 0.302, P = .004).
CONCLUSION: SWE may provide a useful non-invasive tool for evaluating upper airway muscle characteristics in OSA. Associations between upper airway muscle stiffness and polysomnographic parameters were observed; however, these cross-sectional findings should be considered exploratory and hypothesis-generating, requiring confirmation in larger studies.